Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom

Beate I. Escher; Jörg Ahlheim; Alexander Böhme; Dietrich Borchardt; Werner Brack; Georg Braun; John K. Colbourne; Janek Paul Dann; Joern Gessner; Annika Jahnke; Maria König; Nils Klüver; Martin Krauss; Jungeun Lee; Xiaojiang Li; Stefan Lips; Luisa Orsini; Karsten Rinke; Mechthild Schmitt-Jansen; Stefan Scholz; Tobias Schulze; Stephanie Spahr; Nadin Ulrich; Markus Weitere; Elisabeth Varga

doi:10.1038/s44221-024-00297-4

Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom

Beate I. Escher^*, Jörg Ahlheim, Alexander Böhme, Dietrich Borchardt, Werner Brack, Georg Braun, John K. Colbourne, Janek Paul Dann, Joern Gessner, Annika Jahnke, Maria König, Nils Klüver, Martin Krauss, Jungeun Lee, Xiaojiang Li, Stefan Lips, Luisa Orsini, Karsten Rinke, Mechthild Schmitt-Jansen, Stefan ScholzTobias Schulze, Stephanie Spahr, Nadin Ulrich, Markus Weitere, Elisabeth Varga

^*Corresponding author for this work

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Abstract

Prymnesins produced by an algal bloom of Prymnesium parvum led to the death of several hundred tons of freshwater fish in the Oder River in summer 2022. We investigated effects on aquatic life and human cell lines from exposure to extracts of contaminated water collected during the fish kill. We detected B-type prymnesins and >120 organic micropollutants. The micropollutants occurred at concentrations that would cause the predicted mixture risk quotient for aquatic life to exceed the acceptable threshold. Extracts of water and filters (biomass and particulates) induced moderate effects in vivo in algae, daphnids and zebrafish embryos but caused high effects in a human neuronal cell line indicating the presence of neurotoxicants. Mixture toxicity modelling demonstrated that the in vitro neurotoxic effects were mainly caused by the detected B-type prymnesins with minor contributions by organic micropollutants. Complex interactions between natural and anthropogenic toxicants may underestimate threats to aquatic ecosystems.

Original language	English
Pages (from-to)	889-898
Number of pages	10
Journal	Nature Water
Volume	2
Issue number	9
DOIs	https://doi.org/10.1038/s44221-024-00297-4
Publication status	Published - 6 Sept 2024

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Author Correction: Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom
Escher, B. I., Ahlheim, J., Böhme, A., Borchardt, D., Brack, W., Braun, G., Colbourne, J. K., Dann, J. P., Gessner, J., Jahnke, A., König, M., Klüver, N., Krauss, M., Lee, J., Li, X., Lips, S., Orsini, L., Rinke, K., Schmitt-Jansen, M. & Scholz, S. & 5 others, Schulze, T., Spahr, S., Ulrich, N., Weitere, M. & Varga, E., Oct 2024, In: Nature Water. 2, 10, 1 p., 1039.
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Escher, B. I., Ahlheim, J., Böhme, A., Borchardt, D., Brack, W., Braun, G., Colbourne, J. K., Dann, J. P., Gessner, J., Jahnke, A., König, M., Klüver, N., Krauss, M., Lee, J., Li, X., Lips, S., Orsini, L., Rinke, K., Schmitt-Jansen, M., ... Varga, E. (2024). Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom. Nature Water, 2(9), 889-898. https://doi.org/10.1038/s44221-024-00297-4

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title = "Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom",

abstract = "Prymnesins produced by an algal bloom of Prymnesium parvum led to the death of several hundred tons of freshwater fish in the Oder River in summer 2022. We investigated effects on aquatic life and human cell lines from exposure to extracts of contaminated water collected during the fish kill. We detected B-type prymnesins and >120 organic micropollutants. The micropollutants occurred at concentrations that would cause the predicted mixture risk quotient for aquatic life to exceed the acceptable threshold. Extracts of water and filters (biomass and particulates) induced moderate effects in vivo in algae, daphnids and zebrafish embryos but caused high effects in a human neuronal cell line indicating the presence of neurotoxicants. Mixture toxicity modelling demonstrated that the in vitro neurotoxic effects were mainly caused by the detected B-type prymnesins with minor contributions by organic micropollutants. Complex interactions between natural and anthropogenic toxicants may underestimate threats to aquatic ecosystems.",

author = "Escher, {Beate I.} and J{\"o}rg Ahlheim and Alexander B{\"o}hme and Dietrich Borchardt and Werner Brack and Georg Braun and Colbourne, {John K.} and Dann, {Janek Paul} and Joern Gessner and Annika Jahnke and Maria K{\"o}nig and Nils Kl{\"u}ver and Martin Krauss and Jungeun Lee and Xiaojiang Li and Stefan Lips and Luisa Orsini and Karsten Rinke and Mechthild Schmitt-Jansen and Stefan Scholz and Tobias Schulze and Stephanie Spahr and Nadin Ulrich and Markus Weitere and Elisabeth Varga",

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doi = "10.1038/s44221-024-00297-4",

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Escher, BI, Ahlheim, J, Böhme, A, Borchardt, D, Brack, W, Braun, G, Colbourne, JK, Dann, JP, Gessner, J, Jahnke, A, König, M, Klüver, N, Krauss, M, Lee, J, Li, X, Lips, S, Orsini, L, Rinke, K, Schmitt-Jansen, M, Scholz, S, Schulze, T, Spahr, S, Ulrich, N, Weitere, M & Varga, E 2024, 'Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom', Nature Water, vol. 2, no. 9, pp. 889-898. https://doi.org/10.1038/s44221-024-00297-4

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T1 - Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom

AU - Escher, Beate I.

AU - Ahlheim, Jörg

AU - Böhme, Alexander

AU - Borchardt, Dietrich

AU - Brack, Werner

AU - Braun, Georg

AU - Colbourne, John K.

AU - Dann, Janek Paul

AU - Gessner, Joern

AU - Jahnke, Annika

AU - König, Maria

AU - Klüver, Nils

AU - Krauss, Martin

AU - Lee, Jungeun

AU - Li, Xiaojiang

AU - Lips, Stefan

AU - Orsini, Luisa

AU - Rinke, Karsten

AU - Schmitt-Jansen, Mechthild

AU - Scholz, Stefan

AU - Schulze, Tobias

AU - Spahr, Stephanie

AU - Ulrich, Nadin

AU - Weitere, Markus

AU - Varga, Elisabeth

PY - 2024/9/6

Y1 - 2024/9/6

N2 - Prymnesins produced by an algal bloom of Prymnesium parvum led to the death of several hundred tons of freshwater fish in the Oder River in summer 2022. We investigated effects on aquatic life and human cell lines from exposure to extracts of contaminated water collected during the fish kill. We detected B-type prymnesins and >120 organic micropollutants. The micropollutants occurred at concentrations that would cause the predicted mixture risk quotient for aquatic life to exceed the acceptable threshold. Extracts of water and filters (biomass and particulates) induced moderate effects in vivo in algae, daphnids and zebrafish embryos but caused high effects in a human neuronal cell line indicating the presence of neurotoxicants. Mixture toxicity modelling demonstrated that the in vitro neurotoxic effects were mainly caused by the detected B-type prymnesins with minor contributions by organic micropollutants. Complex interactions between natural and anthropogenic toxicants may underestimate threats to aquatic ecosystems.

AB - Prymnesins produced by an algal bloom of Prymnesium parvum led to the death of several hundred tons of freshwater fish in the Oder River in summer 2022. We investigated effects on aquatic life and human cell lines from exposure to extracts of contaminated water collected during the fish kill. We detected B-type prymnesins and >120 organic micropollutants. The micropollutants occurred at concentrations that would cause the predicted mixture risk quotient for aquatic life to exceed the acceptable threshold. Extracts of water and filters (biomass and particulates) induced moderate effects in vivo in algae, daphnids and zebrafish embryos but caused high effects in a human neuronal cell line indicating the presence of neurotoxicants. Mixture toxicity modelling demonstrated that the in vitro neurotoxic effects were mainly caused by the detected B-type prymnesins with minor contributions by organic micropollutants. Complex interactions between natural and anthropogenic toxicants may underestimate threats to aquatic ecosystems.

U2 - 10.1038/s44221-024-00297-4

DO - 10.1038/s44221-024-00297-4

M3 - Article

SN - 2731-6084

VL - 2

SP - 889

EP - 898

JO - Nature Water

JF - Nature Water

IS - 9

ER -

Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom

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Author Correction: Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom

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