Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology

Simon Jones; S M V Brockbank; K M Clements; N Le Good; D Campbell; S J Read; M R C Needham; P Newham

doi:10.1016/j.joca.2008.05.001

Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology

Simon Jones, S M V Brockbank, K M Clements, N Le Good, D Campbell, S J Read, M R C Needham, P Newham

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

To examine the role of mitogen-activated protein kinase-activated protein kinase 2 (MK2) in mediating the cellular response to pro-inflammatory cytokines in human primary osteoarthritis (OA) chondrocytes.

Original language	English
Pages (from-to)	124-31
Number of pages	8
Journal	Osteoarthritis and Cartilage
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.joca.2008.05.001
Publication status	Published - Jan 2009

Keywords

Adenoviridae
Peptide Hydrolases
Enzyme Activation
Intracellular Signaling Peptides and Proteins
Humans
Cartilage, Articular
Aged
Chondrocytes
Interleukin-1beta
RNA, Small Interfering
Protein-Serine-Threonine Kinases
Osteoarthritis, Knee
Dinoprostone
MAP Kinase Signaling System
Phosphorylation
Transfection
Cells, Cultured
Genetic Vectors
Middle Aged
Male

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10.1016/j.joca.2008.05.001

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title = "Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology",

abstract = "To examine the role of mitogen-activated protein kinase-activated protein kinase 2 (MK2) in mediating the cellular response to pro-inflammatory cytokines in human primary osteoarthritis (OA) chondrocytes.",

keywords = "Adenoviridae, Peptide Hydrolases, Enzyme Activation, Intracellular Signaling Peptides and Proteins, Humans, Cartilage, Articular, Aged, Chondrocytes, Interleukin-1beta, RNA, Small Interfering, Protein-Serine-Threonine Kinases, Osteoarthritis, Knee, Dinoprostone, MAP Kinase Signaling System, Phosphorylation, Transfection, Cells, Cultured, Genetic Vectors, Middle Aged, Male",

author = "Simon Jones and Brockbank, \{S M V\} and Clements, \{K M\} and \{Le Good\}, N and D Campbell and Read, \{S J\} and Needham, \{M R C\} and P Newham",

year = "2009",

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doi = "10.1016/j.joca.2008.05.001",

language = "English",

volume = "17",

pages = "124--31",

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T1 - Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology

AU - Jones, Simon

AU - Brockbank, S M V

AU - Clements, K M

AU - Le Good, N

AU - Campbell, D

AU - Read, S J

AU - Needham, M R C

AU - Newham, P

PY - 2009/1

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N2 - To examine the role of mitogen-activated protein kinase-activated protein kinase 2 (MK2) in mediating the cellular response to pro-inflammatory cytokines in human primary osteoarthritis (OA) chondrocytes.

AB - To examine the role of mitogen-activated protein kinase-activated protein kinase 2 (MK2) in mediating the cellular response to pro-inflammatory cytokines in human primary osteoarthritis (OA) chondrocytes.

KW - Adenoviridae

KW - Peptide Hydrolases

KW - Enzyme Activation

KW - Intracellular Signaling Peptides and Proteins

KW - Humans

KW - Cartilage, Articular

KW - Aged

KW - Chondrocytes

KW - Interleukin-1beta

KW - RNA, Small Interfering

KW - Protein-Serine-Threonine Kinases

KW - Osteoarthritis, Knee

KW - Dinoprostone

KW - MAP Kinase Signaling System

KW - Phosphorylation

KW - Transfection

KW - Cells, Cultured

KW - Genetic Vectors

KW - Middle Aged

KW - Male

UR - https://www.scopus.com/pages/publications/57549091806

U2 - 10.1016/j.joca.2008.05.001

DO - 10.1016/j.joca.2008.05.001

M3 - Article

C2 - 18562219

SN - 1522-9653

VL - 17

SP - 124

EP - 131

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

IS - 1

ER -

Mitogen-activated protein kinase-activated protein kinase 2 (MK2) modulates key biological pathways associated with OA disease pathology

Abstract

Keywords

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