Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral naive and experienced patients

L Xu; S Hue; Diana Ratcliffe; Judith Workman; S Jackson; Patricia Cane; Deenan Pillay

doi:10.1097/00002030-200208160-00016

Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral naive and experienced patients

L Xu
, S Hue
, Diana Ratcliffe
, Judith Workman
, S Jackson
, Patricia Cane
, Deenan Pillay

Research output: Contribution to journal › Article

51 Citations (Scopus)

Abstract

In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.

Original language	English
Pages (from-to)	1684-6
Number of pages	3
Journal	Aids
Volume	16
DOIs	https://doi.org/10.1097/00002030-200208160-00016
Publication status	Published - 1 Jan 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1097/00002030-200208160-00016

Cite this

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title = "Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral naive and experienced patients",

abstract = "In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.",

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AU - Xu, L

AU - Hue, S

AU - Ratcliffe, Diana

AU - Workman, Judith

AU - Jackson, S

AU - Cane, Patricia

AU - Pillay, Deenan

PY - 2002/1/1

Y1 - 2002/1/1

N2 - In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.

AB - In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.

UR - https://www.scopus.com/pages/publications/0037119027

U2 - 10.1097/00002030-200208160-00016

DO - 10.1097/00002030-200208160-00016

M3 - Article

C2 - 12172092

VL - 16

SP - 1684

EP - 1686

JO - Aids

JF - Aids

ER -

Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral naive and experienced patients

Abstract

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