Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral naive and experienced patients

L Xu; S Hue; Diana Ratcliffe; Judith Workman; S Jackson; Patricia Cane; Deenan Pillay

doi:10.1097/00002030-200208160-00016

Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral naive and experienced patients

L Xu, S Hue, Diana Ratcliffe, Judith Workman, S Jackson, Patricia Cane, Deenan Pillay

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Abstract

In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.

Original language	English
Pages (from-to)	1684-6
Number of pages	3
Journal	Aids
Volume	16
DOIs	https://doi.org/10.1097/00002030-200208160-00016
Publication status	Published - 1 Jan 2002

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10.1097/00002030-200208160-00016

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abstract = "In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.",

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AU - Xu, L

AU - Hue, S

AU - Ratcliffe, Diana

AU - Workman, Judith

AU - Jackson, S

AU - Cane, Patricia

AU - Pillay, Deenan

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AB - In-vitro differences in T-20 susceptibility among HIV-1 subtypes have been reported. We therefore studied the T-20 binding domain of a variety of virus subtypes from both antiretroviral-naive and -experienced patients. Minimal variation in the HR-1 region of gp41 was observed, especially within the region responsible for T-20 resistance. Any subtype differences in T-20 susceptibility do not appear to be related to HR-1 genetic variation.

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M3 - Article

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JO - Aids

JF - Aids

ER -

Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral naive and experienced patients

Abstract

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