Abstract
Protein-protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. α-Helix mimetics - small molecules that reproduce the spatial projection of key residues from an α-helix involved in a PPI - are attractive generic templates for development of screening libraries, however library syntheses of α-helix mimetics with diverse functionality are less established. This manuscript describes the automated, microwave assisted solid phase synthesis based on one such scaffold; an N-alkylated oligobenzamide.
Original language | English |
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Pages (from-to) | 4034-4040 |
Number of pages | 7 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 21 |
Issue number | 14 |
DOIs | |
Publication status | Published - 15 Jul 2013 |
Bibliographical note
Funding Information:This work builds on previous studies by Dr. F. Campbell and was supported by Yorkshire Cancer Research (L348) and the European Research Council (240324).
Keywords
- Aromatic oligoamide
- Automated solid phase synthesis
- Helix mimetic
- Protein-protein interactions
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry