Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

Kérya Long, Thomas A. Edwards, Andrew J. Wilson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Protein-protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. α-Helix mimetics - small molecules that reproduce the spatial projection of key residues from an α-helix involved in a PPI - are attractive generic templates for development of screening libraries, however library syntheses of α-helix mimetics with diverse functionality are less established. This manuscript describes the automated, microwave assisted solid phase synthesis based on one such scaffold; an N-alkylated oligobenzamide.

Original languageEnglish
Pages (from-to)4034-4040
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume21
Issue number14
DOIs
Publication statusPublished - 15 Jul 2013

Bibliographical note

Funding Information:
This work builds on previous studies by Dr. F. Campbell and was supported by Yorkshire Cancer Research (L348) and the European Research Council (240324).

Keywords

  • Aromatic oligoamide
  • Automated solid phase synthesis
  • Helix mimetic
  • Protein-protein interactions

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics'. Together they form a unique fingerprint.

Cite this