Micromanipulation measurements of biological materials

C. R. Thomas*, Z. Zhang, C. Cowen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


Micromanipulation enables the mechanical properties of microscopic biological particles to be measured in particular cells. It is capable of measurements at high deformations, including up to cell bursting. Particles as small as 1 μm, with breaking forces as low as 1 μN, can be characterised. The method can be enhanced by mechanical modelling to allow intrinsic mechanical properties such as the cell wall elastic modulus to be estimated. Present and potential applications include studying yeast and bacterial cell disruption, mechanical damage to animal cells in suspension cultures and filamentous microorganisms in submerged fermentations, plant cell behaviour in food processing, and flocculation processes.

Original languageEnglish
Pages (from-to)531-537
Number of pages7
JournalBiotechnology Letters
Issue number7
Publication statusPublished - 2000


  • Biological materials
  • Bioprocessing
  • Cells
  • Mechanical property
  • Micromanipulation

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Microbiology


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