Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life

Henrik M. Roager; Catherine Stanton; Lindsay J. Hall

doi:10.1080/19490976.2023.2192151

Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life

Henrik M. Roager^*, Catherine Stanton, Lindsay J. Hall

^*Corresponding author for this work

Microbes, Infections and Microbiomes

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

110 Downloads (Pure)

Abstract

The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut microbial metabolism and the resulting small molecules (metabolites) has been rather limited. However, technological and computational advances are now enabling researchers to profile the plethora of metabolites in the infant gut, allowing for improved understanding of how gut microbial-derived metabolites drive microbiome community structuring and host-microbial interactions. Here, we review the current knowledge on development of the infant gut microbiota and metabolism within the first year of life, and discuss how these microbial metabolites are key for enhancing our basic understanding of interactions during the early life developmental window.

Original language	English
Article number	2192151
Number of pages	22
Journal	Gut Microbes
Volume	15
Issue number	1
Early online date	21 Mar 2023
DOIs	https://doi.org/10.1080/19490976.2023.2192151
Publication status	Published - 31 Dec 2023

Bibliographical note

Funding Information:
This work was supported by the Independent Research Fund Denmark (MOTILITY; grant no. 0171-00006B to H.M.R.). LJH is supported by Wellcome Trust Investigator Award 220876/Z/20/Z; the Biotechnology and Biological Sciences Research Council (BBSRC), Institute Strategic Programme Gut Microbes and Health BB/R012490/1, and its constituent projects BBS/E/F/000PR10353 and BBS/E/F/000PR10356. CS is supported by Science Foundation Ireland, APC Microbiome Ireland and Vistamilk. The funders had no role in decision to publish and preparation of the manuscript.

Publisher Copyright:
© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

Keywords

diet
health
host
infants
Metabolites
metabolomics
microbiota

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Gastroenterology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/19490976.2023.2192151Licence: Creative Commons: Attribution (CC BY)

RoagerH2023MicrobialFinal published version, 4.5 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

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abstract = "The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut microbial metabolism and the resulting small molecules (metabolites) has been rather limited. However, technological and computational advances are now enabling researchers to profile the plethora of metabolites in the infant gut, allowing for improved understanding of how gut microbial-derived metabolites drive microbiome community structuring and host-microbial interactions. Here, we review the current knowledge on development of the infant gut microbiota and metabolism within the first year of life, and discuss how these microbial metabolites are key for enhancing our basic understanding of interactions during the early life developmental window.",

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Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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