Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory

Guanmin Meng; Tanya M Monaghan; Niharika A Duggal; Paddy Tighe; Farhad Peerani

doi:10.1093/ecco-jcc/jjad025

Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory

Guanmin Meng, Tanya M Monaghan, Niharika A Duggal, Paddy Tighe, Farhad Peerani^*

^*Corresponding author for this work

Inflammation and Ageing

Research output: Contribution to journal › Review article › peer-review

Abstract

Elderly-onset inflammatory bowel disease [IBD] patients exhibit a distinct natural history compared to younger IBD patients, with unique disease phenotypes, differential responses to therapy, and increased surgical morbidity and mortality. Despite the foreseeable high demand for personalized medicine and specialized IBD care in the elderly, current paradigms of IBD management fail to capture the required nuances of care for elderly-onset IBD patients. Our review postulates the roles of systemic and mucosal immunosenescence, inflammageing and a dysbiotic microbial ecosystem in the pathophysiology of elderly-onset IBD. Ultimately, a better understanding of elderly-onset IBD can lead to improved patient outcomes and the tailoring of future preventative and treatment strategies.

Original language	English
Pages (from-to)	1309-1325
Number of pages	17
Journal	Journal of Crohn's & Colitis
Volume	17
Issue number	8
Early online date	20 Feb 2023
DOIs	https://doi.org/10.1093/ecco-jcc/jjad025
Publication status	Published - Aug 2023

Bibliographical note

Funding:
This work was supported by the Innovations in IBD grant from Crohn’s and Colitis Canada.

Copyright:
© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: [email protected].

Keywords

Humans
Ecosystem
Inflammatory Bowel Diseases/therapy

Access to Document

10.1093/ecco-jcc/jjad025Licence: None: All rights reserved

https://nottingham-repository.worktribe.com/output/17375968

Cite this

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title = "Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory",

abstract = "Elderly-onset inflammatory bowel disease [IBD] patients exhibit a distinct natural history compared to younger IBD patients, with unique disease phenotypes, differential responses to therapy, and increased surgical morbidity and mortality. Despite the foreseeable high demand for personalized medicine and specialized IBD care in the elderly, current paradigms of IBD management fail to capture the required nuances of care for elderly-onset IBD patients. Our review postulates the roles of systemic and mucosal immunosenescence, inflammageing and a dysbiotic microbial ecosystem in the pathophysiology of elderly-onset IBD. Ultimately, a better understanding of elderly-onset IBD can lead to improved patient outcomes and the tailoring of future preventative and treatment strategies.",

keywords = "Humans, Ecosystem, Inflammatory Bowel Diseases/therapy",

author = "Guanmin Meng and Monaghan, {Tanya M} and Duggal, {Niharika A} and Paddy Tighe and Farhad Peerani",

note = "Funding: This work was supported by the Innovations in IBD grant from Crohn{\textquoteright}s and Colitis Canada. Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn{\textquoteright}s and Colitis Organisation. All rights reserved. For permissions, please email: [email protected].",

year = "2023",

month = aug,

doi = "10.1093/ecco-jcc/jjad025",

language = "English",

volume = "17",

pages = "1309--1325",

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T2 - Unchartered Territory

AU - Meng, Guanmin

AU - Monaghan, Tanya M

AU - Duggal, Niharika A

AU - Tighe, Paddy

AU - Peerani, Farhad

N1 - Funding: This work was supported by the Innovations in IBD grant from Crohn’s and Colitis Canada. Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: [email protected].

PY - 2023/8

Y1 - 2023/8

N2 - Elderly-onset inflammatory bowel disease [IBD] patients exhibit a distinct natural history compared to younger IBD patients, with unique disease phenotypes, differential responses to therapy, and increased surgical morbidity and mortality. Despite the foreseeable high demand for personalized medicine and specialized IBD care in the elderly, current paradigms of IBD management fail to capture the required nuances of care for elderly-onset IBD patients. Our review postulates the roles of systemic and mucosal immunosenescence, inflammageing and a dysbiotic microbial ecosystem in the pathophysiology of elderly-onset IBD. Ultimately, a better understanding of elderly-onset IBD can lead to improved patient outcomes and the tailoring of future preventative and treatment strategies.

AB - Elderly-onset inflammatory bowel disease [IBD] patients exhibit a distinct natural history compared to younger IBD patients, with unique disease phenotypes, differential responses to therapy, and increased surgical morbidity and mortality. Despite the foreseeable high demand for personalized medicine and specialized IBD care in the elderly, current paradigms of IBD management fail to capture the required nuances of care for elderly-onset IBD patients. Our review postulates the roles of systemic and mucosal immunosenescence, inflammageing and a dysbiotic microbial ecosystem in the pathophysiology of elderly-onset IBD. Ultimately, a better understanding of elderly-onset IBD can lead to improved patient outcomes and the tailoring of future preventative and treatment strategies.

KW - Humans

KW - Ecosystem

KW - Inflammatory Bowel Diseases/therapy

U2 - 10.1093/ecco-jcc/jjad025

DO - 10.1093/ecco-jcc/jjad025

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ER -

Microbial-Immune Crosstalk in Elderly-Onset Inflammatory Bowel Disease: Unchartered Territory

Abstract

Bibliographical note

Keywords

Access to Document

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Cite this