Metastatic Bifocal Germinoma With Dramatic Early Steroid Response, Utility of Circulating miR-371a-3p and Vinblastine Monotherapy Prior to Definitive Craniospinal Irradiation

Cinzia G. Scarpini; Dawn Ward; Poe Phyu; Ibrahim Jalloh; Nicky Thorp; Benjamin G. Fisher; A. Emile J. Hendriks; Lyndsay Salisbury; James C. Nicholson; Thankamma Ajithkumar; Gail Horan; G. A. Amos Burke; Nicholas Coleman; Kieren Allinson; Matthew J. Murray

doi:10.1111/nan.70030

Metastatic Bifocal Germinoma With Dramatic Early Steroid Response, Utility of Circulating miR-371a-3p and Vinblastine Monotherapy Prior to Definitive Craniospinal Irradiation

Cinzia G. Scarpini
, Dawn Ward
, Poe Phyu
, Ibrahim Jalloh
, Nicky Thorp
, Benjamin G. Fisher
, A. Emile J. Hendriks
, Lyndsay Salisbury
, James C. Nicholson
, Thankamma Ajithkumar
, Gail Horan
, G. A. Amos Burke
, Nicholas Coleman
, Kieren Allinson
, Matthew J. Murray^*

^*Corresponding author for this work

Cancer Research UK Clinical Trials Unit

Research output: Contribution to journal › Letter › peer-review

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Original language	English
Article number	e70030
Number of pages	6
Journal	Neuropathology and Applied Neurobiology
Volume	51
Issue number	4
Early online date	5 Jul 2025
DOIs	https://doi.org/10.1111/nan.70030
Publication status	Published - Aug 2025

Keywords

cytokine
dexamethasone
germ cell tumour
germinoma
lymphocyte
miR-371a-3p

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Neurology
Clinical Neurology
Physiology (medical)

Access to Document

10.1111/nan.70030Licence: Creative Commons: Attribution (CC BY)

ScarpiniC2025MetastaticFinal published version, 1.58 MBLicence: Creative Commons: Attribution (CC BY)

Cite this

Scarpini, CG., Ward, D., Phyu, P., Jalloh, I., Thorp, N., Fisher, BG., Hendriks, A. EJ., Salisbury, L., Nicholson, JC., Ajithkumar, T., Horan, G., Burke, G. A. A., Coleman, N., Allinson, K., & Murray, MJ. (2025). Metastatic Bifocal Germinoma With Dramatic Early Steroid Response, Utility of Circulating miR-371a-3p and Vinblastine Monotherapy Prior to Definitive Craniospinal Irradiation. Neuropathology and Applied Neurobiology, 51(4), Article e70030. https://doi.org/10.1111/nan.70030

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title = "Metastatic Bifocal Germinoma With Dramatic Early Steroid Response, Utility of Circulating miR-371a-3p and Vinblastine Monotherapy Prior to Definitive Craniospinal Irradiation",

keywords = "cytokine, dexamethasone, germ cell tumour, germinoma, lymphocyte, miR-371a-3p",

author = "Cinzia G. Scarpini and Dawn Ward and Poe Phyu and Ibrahim Jalloh and Nicky Thorp and Benjamin G. Fisher and Hendriks, \{A. Emile J.\} and Lyndsay Salisbury and James C. Nicholson and Thankamma Ajithkumar and Gail Horan and Burke, \{G. A. Amos\} and Nicholas Coleman and Kieren Allinson and Matthew J. Murray",

year = "2025",

month = aug,

doi = "10.1111/nan.70030",

language = "English",

volume = "51",

journal = "Neuropathology and Applied Neurobiology",

issn = "0305-1846",

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Scarpini, CG, Ward, D, Phyu, P, Jalloh, I, Thorp, N, Fisher, BG, Hendriks, AEJ, Salisbury, L, Nicholson, JC, Ajithkumar, T, Horan, G, Burke, GAA, Coleman, N, Allinson, K & Murray, MJ 2025, 'Metastatic Bifocal Germinoma With Dramatic Early Steroid Response, Utility of Circulating miR-371a-3p and Vinblastine Monotherapy Prior to Definitive Craniospinal Irradiation', Neuropathology and Applied Neurobiology, vol. 51, no. 4, e70030. https://doi.org/10.1111/nan.70030

Metastatic Bifocal Germinoma With Dramatic Early Steroid Response, Utility of Circulating miR-371a-3p and Vinblastine Monotherapy Prior to Definitive Craniospinal Irradiation. / Scarpini, Cinzia G.; Ward, Dawn; Phyu, Poe et al.
In: Neuropathology and Applied Neurobiology, Vol. 51, No. 4, e70030, 08.2025.

Research output: Contribution to journal › Letter › peer-review

TY - JOUR

T1 - Metastatic Bifocal Germinoma With Dramatic Early Steroid Response, Utility of Circulating miR-371a-3p and Vinblastine Monotherapy Prior to Definitive Craniospinal Irradiation

AU - Scarpini, Cinzia G.

AU - Ward, Dawn

AU - Phyu, Poe

AU - Jalloh, Ibrahim

AU - Thorp, Nicky

AU - Fisher, Benjamin G.

AU - Hendriks, A. Emile J.

AU - Salisbury, Lyndsay

AU - Nicholson, James C.

AU - Ajithkumar, Thankamma

AU - Horan, Gail

AU - Burke, G. A. Amos

AU - Coleman, Nicholas

AU - Allinson, Kieren

AU - Murray, Matthew J.

PY - 2025/8

Y1 - 2025/8

KW - cytokine

KW - dexamethasone

KW - germ cell tumour

KW - germinoma

KW - lymphocyte

KW - miR-371a-3p

UR - https://www.scopus.com/pages/publications/105009717923

U2 - 10.1111/nan.70030

DO - 10.1111/nan.70030

M3 - Letter

AN - SCOPUS:105009717923

SN - 0305-1846

VL - 51

JO - Neuropathology and Applied Neurobiology

JF - Neuropathology and Applied Neurobiology

IS - 4

M1 - e70030

ER -