Metabolism at the centre of the host-microbe relationship

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Abstract

Maintaining homoeostatic host-microbe interactions is vital for host immune function. The gut microbiota shapes the host immune system and the immune system reciprocally shapes and modifies the gut microbiota. However, our understanding of how these microbes are tolerated and how individual, or communities of, gut microbes influence host function is limited. This review will focus on metabolites as key mediators of this complex host-microbe relationship. It will look at the central role of epithelial metabolism in shaping the gut microbiota, how microbial metabolites influence the epithelium and the mucosal and peripheral immune system, and how the immune system shapes microbial composition and metabolism. Finally, this review will look at how metabolites are involved in cross-talk between different members of the microbiota and their role during infections.

Original languageEnglish
Pages (from-to)193-204
Number of pages12
JournalClinical and Experimental Immunology
Volume197
Issue number2
Early online date20 May 2019
DOIs
Publication statusPublished - Aug 2019

Keywords

  • autoimmunity
  • dysbiosis
  • host-pathogen interactions
  • infection
  • inflammation
  • physiological hypoxia

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