Metabolic Syndrome and the Immunological Affair with the Blood Brain Barrier

Claudio Mauro, Veronica De Rosa, Federica Marelli-berg, Egle Solito

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)
95 Downloads (Pure)


Epidemiological studies reveal an increased incidence of obesity worldwide, which is associated with increased prevalence and severity of cognitive disorders. The blood–brain barrier (BBB) represents the interface between the peripheral circulation and the brain, and plays a fundamental role in the cross-talk between these two compartments. The homeostatic function of the BBB is the protection of the brain from peripheral insult/inflammation. Alterations in the function of the BBB lead to pathologies of the central nervous system. Recently, metabolic imbalance has been shown to be an important risk factor associated with the decline of BBB integrity and function. This has direct etiological consequences on a variety of cerebrovascular and neurodegenerative pathologies with great impact to society. Priority areas for future preclinical research include strategies to improve clinicians’ ability to diagnose, prevent, and manage BBB abnormalities. In sharp contrast with epidemiological studies and clinical needs, little is known about the mechanisms that link metabolic syndrome to BBB functionality and cognitive disorders. Our view is that immune responses caused by metabolic stress might play a major role in this conundrum.
Original languageEnglish
Article number677
Number of pages6
JournalFrontiers in immunology
Publication statusPublished - Jan 2015


  • blood–brain barrier
  • metabolism
  • immune response
  • leukocytes
  • diet


Dive into the research topics of 'Metabolic Syndrome and the Immunological Affair with the Blood Brain Barrier'. Together they form a unique fingerprint.

Cite this