Abstract
One mechanism proposed to explain age-dependent changes has been the "Ca2+ hypothesis" of aging. Data indicate that most changes in the Ca2+ homeostasis of the cerebellar granule neurons appear only when the aged neurons are exposed to higher levels of stimulation and that these changes are secondary to metabolic limitations imposed by altered mitochondrial function.
| Original language | English |
|---|---|
| Pages (from-to) | 19-23 |
| Number of pages | 5 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1019 |
| DOIs | |
| Publication status | Published - 1 Jun 2004 |
Keywords
- [Ca2+1](i)
- homeostasis
- neuron
- cerebellar granule
- brain
- aging