Metabolic substrates of neuronal ageing

Emil Toescu, Jie Xiong

    Research output: Contribution to journalArticle

    10 Citations (Scopus)


    One mechanism proposed to explain age-dependent changes has been the "Ca2+ hypothesis" of aging. Data indicate that most changes in the Ca2+ homeostasis of the cerebellar granule neurons appear only when the aged neurons are exposed to higher levels of stimulation and that these changes are secondary to metabolic limitations imposed by altered mitochondrial function.
    Original languageEnglish
    Pages (from-to)19-23
    Number of pages5
    JournalAnnals of the New York Academy of Sciences
    Publication statusPublished - 1 Jun 2004


    • [Ca2+1](i)
    • homeostasis
    • neuron
    • cerebellar granule
    • brain
    • aging


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