TY - JOUR
T1 - Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
AU - Houlston, Richard S
AU - Maher, Eamonn
AU - Cazier, Jean-Baptiste
AU - Colorectal Tumour Gene Identification (CORGI) Consortium
AU - The COIN Collaborative Group
AU - The COINB Collaborative Group
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55 x 10(-10) and rs6687758, OR = 1.09, P = 2.27 x 10(-9)), 3q26.2 (rs10936599, OR = 0.93, P = 3.39 x 10(-8)), 12q13.13 (rs11169552, OR = 0.92, P = 1.89 x 10(-10) and rs7136702, OR = 1.06, P = 4.02 x 10(-8)) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89 x 10(-10)). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered.
AB - Genome-wide association studies (GWAS) have identified ten loci harboring common variants that influence risk of developing colorectal cancer (CRC). To enhance the power to identify additional CRC risk loci, we conducted a meta-analysis of three GWAS from the UK which included a total of 3,334 affected individuals (cases) and 4,628 controls followed by multiple validation analyses including a total of 18,095 cases and 20,197 controls. We identified associations at four new CRC risk loci: 1q41 (rs6691170, odds ratio (OR) = 1.06, P = 9.55 x 10(-10) and rs6687758, OR = 1.09, P = 2.27 x 10(-9)), 3q26.2 (rs10936599, OR = 0.93, P = 3.39 x 10(-8)), 12q13.13 (rs11169552, OR = 0.92, P = 1.89 x 10(-10) and rs7136702, OR = 1.06, P = 4.02 x 10(-8)) and 20q13.33 (rs4925386, OR = 0.93, P = 1.89 x 10(-10)). In addition to identifying new CRC risk loci, this analysis provides evidence that additional CRC-associated variants of similar effect size remain to be discovered.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-78049353079&partnerID=MN8TOARS
U2 - 10.1038/ng.670
DO - 10.1038/ng.670
M3 - Article
SN - 1546-1718
VL - 42
SP - 973
EP - 977
JO - Nature Genetics
JF - Nature Genetics
IS - 11
ER -
