Meta-Analysis of Brain Weight in Schizophrenia

PJ Harrison, Nick Freemantle, J Geddes

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    57 Citations (Scopus)


    Brain weight is often said to be decreased in schizophrenia, but a reduction has only been found in a minority of studies. We have therefore carried out a meta-analysis to answer this basic neuropathological question. Data were identified from literature searches and from contacting researchers in the field who were invited to submit unpublished data. Inclusion criteria were: an operational diagnosis of schizophrenia, or comparison subjects with no neurological or psychiatric history, aged 18 or over, for whom brain weight, age and sex were known. Exclusion criteria were: a history of head injury, epilepsy, substance dependence or leucotomy; neuropathological evidence of neurodegenerative disorder or focal brain lesion. Results were analysed by multilevel modelling. Brain weight was, as expected, related to age and sex (both p
    Original languageEnglish
    Pages (from-to)25-34
    Number of pages10
    JournalSchizophrenia Research
    Issue number1
    Publication statusPublished - 1 Nov 2003


    • psychosis
    • schizophrenia
    • neuropathology
    • gender
    • suicide


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