Abstract
Brain weight is often said to be decreased in schizophrenia, but a reduction has only been found in a minority of studies. We have therefore carried out a meta-analysis to answer this basic neuropathological question. Data were identified from literature searches and from contacting researchers in the field who were invited to submit unpublished data. Inclusion criteria were: an operational diagnosis of schizophrenia, or comparison subjects with no neurological or psychiatric history, aged 18 or over, for whom brain weight, age and sex were known. Exclusion criteria were: a history of head injury, epilepsy, substance dependence or leucotomy; neuropathological evidence of neurodegenerative disorder or focal brain lesion. Results were analysed by multilevel modelling. Brain weight was, as expected, related to age and sex (both p
| Original language | English |
|---|---|
| Pages (from-to) | 25-34 |
| Number of pages | 10 |
| Journal | Schizophrenia Research |
| Volume | 64 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Nov 2003 |
Keywords
- psychosis
- schizophrenia
- neuropathology
- gender
- suicide
