TY - JOUR
T1 - Meta-Analysis of Brain Weight in Schizophrenia
AU - Harrison, PJ
AU - Freemantle, Nick
AU - Geddes, J
PY - 2003/11/1
Y1 - 2003/11/1
N2 - Brain weight is often said to be decreased in schizophrenia, but a reduction has only been found in a minority of studies. We have therefore carried out a meta-analysis to answer this basic neuropathological question. Data were identified from literature searches and from contacting researchers in the field who were invited to submit unpublished data. Inclusion criteria were: an operational diagnosis of schizophrenia, or comparison subjects with no neurological or psychiatric history, aged 18 or over, for whom brain weight, age and sex were known. Exclusion criteria were: a history of head injury, epilepsy, substance dependence or leucotomy; neuropathological evidence of neurodegenerative disorder or focal brain lesion. Results were analysed by multilevel modelling. Brain weight was, as expected, related to age and sex (both p
AB - Brain weight is often said to be decreased in schizophrenia, but a reduction has only been found in a minority of studies. We have therefore carried out a meta-analysis to answer this basic neuropathological question. Data were identified from literature searches and from contacting researchers in the field who were invited to submit unpublished data. Inclusion criteria were: an operational diagnosis of schizophrenia, or comparison subjects with no neurological or psychiatric history, aged 18 or over, for whom brain weight, age and sex were known. Exclusion criteria were: a history of head injury, epilepsy, substance dependence or leucotomy; neuropathological evidence of neurodegenerative disorder or focal brain lesion. Results were analysed by multilevel modelling. Brain weight was, as expected, related to age and sex (both p
KW - psychosis
KW - schizophrenia
KW - neuropathology
KW - gender
KW - suicide
UR - http://www.scopus.com/inward/record.url?scp=0141456233&partnerID=8YFLogxK
U2 - 10.1016/S0920-9964(02)00502-9
DO - 10.1016/S0920-9964(02)00502-9
M3 - Article
C2 - 14511798
SN - 0920-9964
VL - 64
SP - 25
EP - 34
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1
ER -
