Mesenchymal stem cells: the fibroblasts' new clothes?

M A Haniffa, Matthew P. Collin, Christopher Buckley, Francesco Dazzi

Research output: Contribution to journalReview articlepeer-review

262 Citations (Scopus)
97 Downloads (Pure)

Abstract

Mesenchymal stem cells are adherent stromal cells, initially isolated from the bone marrow, characterized by their ability to differentiate into mesenchymal tissues such as bone, cartilage and fat. They have also been shown to suppress immune responses in vitro. Because of these properties, mesenchymal stem cells have recently received a very high profile. Despite the dramatic benefits reported in early phase clinical trials, their functions remain poorly understood. Particularly, several questions remain concerning the origin of mesenchymal stem cells and their relationship to other stromal cells such as fibroblasts. Whereas clear gene expression signatures are imprinted in stromal cells of different anatomical origins, the anti-proliferative effects of mesenchymal stem cells and fibroblasts and their potential to differentiate appear to be common features between these two cell types. In this review, we summarize recent studies in the context of historical and often neglected stromal cell literature, and present the evidence that mesenchymal stem cells and fibroblasts share much more in common than previously recognized.
Original languageEnglish
Pages (from-to)258-263
Number of pages6
JournalHaematologica
Volume94
Issue number2
DOIs
Publication statusPublished - 1 Feb 2009

Keywords

  • mesenchymal stem cells
  • graft-versus-host disease
  • fibroblasts

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