Memory traces of long-range coordinated oscillations in the sleeping human brain

Giovanni Piantoni, Ysbrand D. Van Der Werf, Ole Jensen, Eus J. W. Van Someren

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Cognition involves coordinated activity across distributed neuronal networks. Neuronal activity during learning triggers cortical plasticity that allows for reorganization of the neuronal network and integration of new information. Animal studies have shown post-learning reactivation of learning-elicited neuronal network activity during subsequent sleep, supporting consolidation of the reorganization. However, no previous studies, to our knowledge, have demonstrated reactivation of specific learning-elicited long-range functional connectivity during sleep in humans. We here show reactivation of learning-induced long-range synchronization of magnetoencephalography power fluctuations in human sleep. Visuomotor learning elicited a specific profile of long-range cortico-cortical synchronization of slow (0.1 Hz) fluctuations in beta band (12-30 Hz) power. The parieto-occipital part of this synchronization profile reappeared in delta band (1-3.5 Hz) power fluctuations during subsequent sleep, but not during the intervening wakefulness period. Individual differences in the reactivated synchronization predicted postsleep performance improvement. The presleep resting-state synchronization profile was not reactivated during sleep. The findings demonstrate reactivation of long-range coordination of neuronal activity in humans, more specifically of reactivation of coupling of infra-slow fluctuations in oscillatory power. The spatiotemporal profile of delta power fluctuations during sleep may subserve memory consolidation by echoing coordinated activation elicited by prior learning.

Original languageEnglish
Pages (from-to)67-84
Number of pages18
JournalHuman Brain Mapping
Issue number1
Early online date20 Aug 2014
Publication statusPublished - 1 Jan 2015


  • neuronal network reorganization
  • Brain Mapping
  • Cerebral Cortex
  • oscillations
  • Electroencephalography
  • plasticity
  • reactivation
  • Learning
  • Magnetoencephalography
  • Memory
  • sleep


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