Memory T cells : how might they disrupt the induction of tolerance?

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Clinical and experimental evidences suggest that alloreactive memory T cells may be part of the normal T-cell repertoire and that such cells are detrimental to the survival of foreign organ allografts induced by the administration of conventional immunosuppression or experimental tolerance-inducing therapies. The potential mechanisms by which alloreactive memory T cell may form a barrier to the induction of tolerance will be discussed.
Original languageEnglish
Pages (from-to)S74-S77
Issue number9S
Publication statusPublished - 15 May 2009


  • T-Lymphocytes, Regulatory
  • Graft Rejection
  • Humans
  • Graft Survival
  • Immunologic Memory
  • Transplantation, Homologous
  • Immunosuppressive Agents
  • Immune Tolerance
  • T-Lymphocytes
  • Immunosuppression


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