Memory reconsolidation impairments in sign-tracking to an audiovisual compound stimulus

Mohamed Lamine Drame, Maria Balaet, Jonathan Lee

Research output: Contribution to journalArticlepeer-review

125 Downloads (Pure)


Studies of memory reconsolidation of pavlovian memories have typically employed unimodal conditioned stimuli, despite the use of multimodal compound stimuli in other settings. Here we studied sign-tracking behaviour to a compound audiovisual stimulus. First, we observed not unexpectedly that sign-tracking was poorer to the audiovisual compound than to unimodal visual stimuli. Then, we showed that, depending on the parameters of compound stimulus re-exposure at memory reactivation, systemic MK-801 treatment either impaired extinction to improve sign-tracking at test, or disrupted reconsolidation to impair test behaviour. When memory reactivation consisted of re-exposure to only the auditory component of the compound stimulus, we observed sign-tracking impairments following MK-801 treatment, but only under certain test conditions. This was in contrast to the consistent impairment following reactivation with the full audiovisual compound. Moreover, the parameters of auditory stimulus presentation to enable MK-801-induced impairment at test varied depending on whether the stimulus was presented within or outside the training context. These findings suggest that behaviour under the control of appetitive pavlovian compound stimuli can be modulated by targeting both extinction and reconsolidation, and that it is not necessary to re-expose to the full compound stimulus in order to achieve a degree of modulation of behaviour.

Original languageEnglish
Article number112774
Number of pages8
JournalBehavioural Brain Research
Early online date15 Jun 2020
Publication statusPublished - 1 Sept 2020


  • Autoshaping
  • Destabilization
  • Extinction
  • Pavlovian
  • Reconsolidation
  • Sign tracking

ASJC Scopus subject areas

  • Behavioral Neuroscience


Dive into the research topics of 'Memory reconsolidation impairments in sign-tracking to an audiovisual compound stimulus'. Together they form a unique fingerprint.

Cite this