MEG cortical microstates: spatiotemporal characteristics, dynamics functional connectivity and stimulus-evoked responses

Luke Tait, Jiaxiang Zhang

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Abstract

EEG microstate analysis is an approach to study brain states and their fast transitions in healthy cognition and disease. A key limitation of conventional microstate analysis is that it must be performed at the sensor level, and therefore gives limited anatomical insight. Here, we generalise the microstate methodology to be applicable to source-reconstructed electrophysiological data. Using simulations of a neural-mass network model, we first established the validity and robustness of the proposed method. Using MEG resting-state data, we uncovered ten microstates with distinct spatial distributions of cortical activation. Multivariate pattern analysis demonstrated that source-level microstates were associated with distinct functional connectivity patterns. We further demonstrated that the occurrence probability of MEG microstates were altered by auditory stimuli, exhibiting a hyperactivity of the microstate including the auditory cortex. Our results support the use of source-level microstates as a method for investigating brain dynamic activity and connectivity at the millisecond scale.
Original languageEnglish
Article number119006
Number of pages14
JournalNeuroImage
Volume251
Early online date16 Feb 2022
DOIs
Publication statusPublished - 1 May 2022

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