Mechanochemistry in transition metal-catalyzed reactions

Over the past 15 years, mechanochemistry has developed into a powerful tool for the synthesis of molecules and materials while avoiding the consumption of bulk solvents. With tailored instruments and well-understood milling/grinding techniques, experimentalists are now tackling synthetic problems of increasing complexity, such as implementing the use of a catalyst to enable specific chemical pathways and control reaction selectivity. This Opinion provides a snapshot of the current state of affairs in the field, highlighting recent examples that employ metal-based catalysts under mechanochemical conditions, as well as the context and specific features of the underlying methods.