Mechanochemical synthesis of bismuth active pharmaceutical ingredients, bismuth(III) gallate and bismuth citrate

Daniel Szczerba; Jean-Louis Do; Davin Tan; Hatem M. Titi; Nicolas Geoffroy; María del Carmen Marco de Lucas; Julien Boudon; Ivan Halasz; Tomislav Friščić; Simon A.J. Kimber

doi:10.1039/d4mr00008k

Mechanochemical synthesis of bismuth active pharmaceutical ingredients, bismuth(_III) gallate and bismuth citrate

Daniel Szczerba^*
, Jean-Louis Do
, Davin Tan
, Hatem M. Titi
, Nicolas Geoffroy
, María del Carmen Marco de Lucas
, Julien Boudon
, Ivan Halasz
, Tomislav Friščić^*
, Simon A.J. Kimber^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

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Abstract

Organobismuth compounds have been known for centuries as substances of medical interest, and continue to be used in medicine today. Bismuth active pharmaceutical ingredients (APIs) are used as digestive aids, including in combating Helicobacter pylori, showing antiviral properties. Here we report the mechanochemical synthesis of bismuth gallate and bismuth citrate. In addition, we revisit the previously reported mechanochemical synthesis of bismuth(_III) di- and trisalicylate. In the case of bismuth citrate, which has an unknown structure, we show that hydration induces a reversible transformation to a large (possibly cubic) unit cell.

Original language	English
Pages (from-to)	255-262
Number of pages	8
Journal	RSC Mechanochemistry
Volume	1
Issue number	3
Early online date	19 Apr 2024
DOIs	https://doi.org/10.1039/d4mr00008k
Publication status	Published - 9 Jul 2024

Bibliographical note

Publisher Copyright:
© 2024 RSC.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Chemistry (miscellaneous)
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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Cite this

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title = "Mechanochemical synthesis of bismuth active pharmaceutical ingredients, bismuth(III) gallate and bismuth citrate",

abstract = "Organobismuth compounds have been known for centuries as substances of medical interest, and continue to be used in medicine today. Bismuth active pharmaceutical ingredients (APIs) are used as digestive aids, including in combating Helicobacter pylori, showing antiviral properties. Here we report the mechanochemical synthesis of bismuth gallate and bismuth citrate. In addition, we revisit the previously reported mechanochemical synthesis of bismuth(III) di- and trisalicylate. In the case of bismuth citrate, which has an unknown structure, we show that hydration induces a reversible transformation to a large (possibly cubic) unit cell.",

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day = "9",

doi = "10.1039/d4mr00008k",

language = "English",

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T1 - Mechanochemical synthesis of bismuth active pharmaceutical ingredients, bismuth(III) gallate and bismuth citrate

AU - Szczerba, Daniel

AU - Do, Jean-Louis

AU - Tan, Davin

AU - Titi, Hatem M.

AU - Geoffroy, Nicolas

AU - de Lucas, María del Carmen Marco

AU - Boudon, Julien

AU - Halasz, Ivan

AU - Friščić, Tomislav

AU - Kimber, Simon A.J.

PY - 2024/7/9

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N2 - Organobismuth compounds have been known for centuries as substances of medical interest, and continue to be used in medicine today. Bismuth active pharmaceutical ingredients (APIs) are used as digestive aids, including in combating Helicobacter pylori, showing antiviral properties. Here we report the mechanochemical synthesis of bismuth gallate and bismuth citrate. In addition, we revisit the previously reported mechanochemical synthesis of bismuth(III) di- and trisalicylate. In the case of bismuth citrate, which has an unknown structure, we show that hydration induces a reversible transformation to a large (possibly cubic) unit cell.

AB - Organobismuth compounds have been known for centuries as substances of medical interest, and continue to be used in medicine today. Bismuth active pharmaceutical ingredients (APIs) are used as digestive aids, including in combating Helicobacter pylori, showing antiviral properties. Here we report the mechanochemical synthesis of bismuth gallate and bismuth citrate. In addition, we revisit the previously reported mechanochemical synthesis of bismuth(III) di- and trisalicylate. In the case of bismuth citrate, which has an unknown structure, we show that hydration induces a reversible transformation to a large (possibly cubic) unit cell.

UR - https://www.scopus.com/pages/publications/105013966984

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