Mechanisms of microbial escape from phagocyte killing

Leanne M Smith; Robin C May

doi:10.1042/BST20130014

Mechanisms of microbial escape from phagocyte killing

Biosciences

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Phagocytosis and phagosome maturation are crucial processes in biology. Phagocytosis and the subsequent digestion of phagocytosed particles occur across a huge diversity of eukaryotes and can be achieved by many different cells within one organism. In parallel, diverse groups of pathogens have evolved mechanisms to avoid killing by phagocytic cells. The present review discusses a key innate immune cell, the macrophage, and highlights the myriad mechanisms microbes have established to escape phagocytic killing.

Original language	English
Pages (from-to)	475-90
Number of pages	16
Journal	Biochemical Society Transactions
Volume	41
Issue number	2
DOIs	https://doi.org/10.1042/BST20130014
Publication status	Published - Apr 2013

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10.1042/BST20130014

DEALING WITH THERAPY-RESISTANT CRYPTOCOCCOSIS BY TARGETING INTRACELLULAR PATHOGENS
May, R. (Principal Investigator)
Medical Research Council
15/10/12 → 14/04/16
Project: Research Councils
Identifying the mechanism of intracellular parasitism by Cryptococcus
May, R. (Principal Investigator)
Medical Research Council
1/10/07 → 30/09/10
Project: Research Councils

Cite this

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title = "Mechanisms of microbial escape from phagocyte killing",

abstract = "Phagocytosis and phagosome maturation are crucial processes in biology. Phagocytosis and the subsequent digestion of phagocytosed particles occur across a huge diversity of eukaryotes and can be achieved by many different cells within one organism. In parallel, diverse groups of pathogens have evolved mechanisms to avoid killing by phagocytic cells. The present review discusses a key innate immune cell, the macrophage, and highlights the myriad mechanisms microbes have established to escape phagocytic killing.",

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AB - Phagocytosis and phagosome maturation are crucial processes in biology. Phagocytosis and the subsequent digestion of phagocytosed particles occur across a huge diversity of eukaryotes and can be achieved by many different cells within one organism. In parallel, diverse groups of pathogens have evolved mechanisms to avoid killing by phagocytic cells. The present review discusses a key innate immune cell, the macrophage, and highlights the myriad mechanisms microbes have established to escape phagocytic killing.

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Mechanisms of microbial escape from phagocyte killing

Abstract

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Projects

DEALING WITH THERAPY-RESISTANT CRYPTOCOCCOSIS BY TARGETING INTRACELLULAR PATHOGENS

Identifying the mechanism of intracellular parasitism by Cryptococcus

Cite this