Mechanisms of Drosophila Dscam mutually exclusive splicing regulation

Yash Hemani, Matthias Soller

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Alternative splicing of pre-mRNA is a major mechanism to increase protein diversity in higher eukaryotes. Dscam, the Drosophila homologue of human DSCAM (Down's syndrome cell adhesion molecule), generates up to 38016 isoforms through mutually exclusive splicing in four variable exon clusters. This enormous molecular diversity is functionally important for wiring of the nervous system and phagocytosis of invading pathogens. Current models explaining this complex splicing regulation include a default repressed state of the variable exon clusters to prevent the splicing together of adjacent exons, the presence of RNA secondary structures important for the release of one specific variable exon from the repressed state and combinatorial interaction of RNA-binding proteins for choosing a specific exon.
Original languageEnglish
Pages (from-to)804-9
Number of pages6
JournalBiochemical Society Transactions
Issue number4
Publication statusPublished - Aug 2012


  • Animals
  • Alternative Splicing
  • RNA-Binding Proteins
  • Drosophila Proteins
  • Nucleic Acid Conformation
  • Drosophila
  • Cell Adhesion Molecules


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