Mechanisms in endocrinology: endocrinology of opioids

Athanasios Fountas, Shu Teng Chai, Chrysoula Kourkouti, Niki Karavitaki

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)
129 Downloads (Pure)

Abstract

The use of opioids has grown substantially over the past two decades reaching the dimensions of a global epidemic. These drugs have effects on multiple levels of the endocrine system through mechanisms which are still not fully elucidated, and awareness of their endocrine sequelae is vital for all specialists prescribing or managing patients on them. Hypogonadism is the most well recognised consequence of opioid use (prevalence 21-86%) which, however, may remain undiagnosed with potential adverse outcomes for the patients. Although less frequent, cortisol deficiency can be also found. Furthermore, there is negative impact on bone health (with reduced bone mineral density and increased fracture risk) and occasionally hyperprolactinaemia, whereas the clinical significance of alterations in other hormones remains to be clarified. Discontinuation or reduction of the opioid and, in cases of chronic pain, consideration of alternative therapies for pain relief are potential management options. Hormonal replacement, especially when the above measures are not practically feasible, needs to be considered. Further studies are needed to clearly establish the prevalence of hormonal abnormalities with various regimes, doses and routes of opioids and to address reliably the long-term benefits and risks of hormonal treatment in patients on opioids. Until evidence-based, safe and cost-effective clinical guidelines become available, periodical assessment of the gonadal and adrenal function (particularly when relevant clinical manifestations are present) and evaluation of the bone health status are advised.
Original languageEnglish
Pages (from-to)R183–R196
Number of pages14
JournalEuropean Journal of Endocrinology
Volume179
Issue number4
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • opioids
  • opiates
  • hypogonadism
  • hypoadrenalism

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