Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

C Pepper; TT Lin; Guy Pratt; S Hewamana; P Brennan; L Hiller; R Hills; R Ward; J Starczynski; B Austen; L Hooper; Tatjana Stankovic; C Fegan

doi:10.1182/blood-2008-05-157131

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

C Pepper
, TT Lin
, Guy Pratt
, S Hewamana
, P Brennan
, L Hiller
, R Hills
, R Ward
, J Starczynski
, B Austen
, L Hooper
, Tatjana Stankovic
, C Fegan

Cancer and Genomic Sciences

Research output: Contribution to journal › Article

185 Citations (Scopus)

Abstract

Bcl-2 family proteins play a critical role in the regulation of apoptosis in chronic lymphocytic leukemia (CLL). However, their association with established prognostic markers is unknown. In this study, we analyzed the expression of Bcl-2, Bax, and Mcl-1 in 185 CLL patients and evaluated their relationship with other prognostic markers, in vitro sensitivity to fludarabine, and clinical outcome. Mcl-1 expression was significantly correlated with stage of disease (P

Original language	English
Pages (from-to)	3807-3817
Number of pages	11
Journal	Blood
Volume	112
Issue number	9
DOIs	https://doi.org/10.1182/blood-2008-05-157131
Publication status	Published - 1 Nov 2008

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Pepper, C., Lin, TT., Pratt, G., Hewamana, S., Brennan, P., Hiller, L., Hills, R., Ward, R., Starczynski, J., Austen, B., Hooper, L., Stankovic, T., & Fegan, C. (2008). Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers. Blood, 112(9), 3807-3817. https://doi.org/10.1182/blood-2008-05-157131

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title = "Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers",

abstract = "Bcl-2 family proteins play a critical role in the regulation of apoptosis in chronic lymphocytic leukemia (CLL). However, their association with established prognostic markers is unknown. In this study, we analyzed the expression of Bcl-2, Bax, and Mcl-1 in 185 CLL patients and evaluated their relationship with other prognostic markers, in vitro sensitivity to fludarabine, and clinical outcome. Mcl-1 expression was significantly correlated with stage of disease (P ",

author = "C Pepper and TT Lin and Guy Pratt and S Hewamana and P Brennan and L Hiller and R Hills and R Ward and J Starczynski and B Austen and L Hooper and Tatjana Stankovic and C Fegan",

year = "2008",

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doi = "10.1182/blood-2008-05-157131",

language = "English",

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Pepper, C, Lin, TT, Pratt, G, Hewamana, S, Brennan, P, Hiller, L, Hills, R, Ward, R, Starczynski, J, Austen, B, Hooper, L, Stankovic, T & Fegan, C 2008, 'Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers', Blood, vol. 112, no. 9, pp. 3807-3817. https://doi.org/10.1182/blood-2008-05-157131

TY - JOUR

T1 - Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

AU - Pepper, C

AU - Lin, TT

AU - Pratt, Guy

AU - Hewamana, S

AU - Brennan, P

AU - Hiller, L

AU - Hills, R

AU - Ward, R

AU - Starczynski, J

AU - Austen, B

AU - Hooper, L

AU - Stankovic, Tatjana

AU - Fegan, C

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Bcl-2 family proteins play a critical role in the regulation of apoptosis in chronic lymphocytic leukemia (CLL). However, their association with established prognostic markers is unknown. In this study, we analyzed the expression of Bcl-2, Bax, and Mcl-1 in 185 CLL patients and evaluated their relationship with other prognostic markers, in vitro sensitivity to fludarabine, and clinical outcome. Mcl-1 expression was significantly correlated with stage of disease (P

AB - Bcl-2 family proteins play a critical role in the regulation of apoptosis in chronic lymphocytic leukemia (CLL). However, their association with established prognostic markers is unknown. In this study, we analyzed the expression of Bcl-2, Bax, and Mcl-1 in 185 CLL patients and evaluated their relationship with other prognostic markers, in vitro sensitivity to fludarabine, and clinical outcome. Mcl-1 expression was significantly correlated with stage of disease (P

U2 - 10.1182/blood-2008-05-157131

DO - 10.1182/blood-2008-05-157131

M3 - Article

C2 - 18599795

SN - 1528-0020

VL - 112

SP - 3807

EP - 3817

JO - Blood

JF - Blood

IS - 9

ER -

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers

Abstract

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