Mathematical modeling of the effects of nutrient competition and bile acid metabolism by the gut microbiota on colonization resistance against Clostridium difficile

Sara Jabbari; Arietta Fleming-Davies; Suzanne L. Robertson; Tri Sri Noor Asih; Cristina  Lanzas; Suzanne  Lenhart; Casey M. Theriot

Mathematical modeling of the effects of nutrient competition and bile acid metabolism by the gut microbiota on colonization resistance against Clostridium difficile

Sara Jabbari, Arietta Fleming-Davies, Suzanne L. Robertson, Tri Sri Noor Asih, Cristina Lanzas, Suzanne Lenhart, Casey M. Theriot

Mathematics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

304 Downloads (Pure)

Abstract

Clostridium difficile is the leading cause of infectious diarrhea in hospitals
and one of the most common healthcare associated infections. Antibiotics alter
the normal gut microbiota and facilitate the colonization of enteric pathogens such as C. difficile. Our objective is to elucidate the role of bile acids and other mechanisms in providing colonization resistance against C. difficile. We formulated and analyzed differential equation models for microbial interactions in the gut and bile acid dynamics, as well as a combined model including both mechanisms. Our analysis indicates that bile acids do not prevent C. difficile colonization, but they regulate the onset of C. difficile colonization and growth after antibiotic perturbation. These results have implications in the development of novel ways to inhibit C. difficile infection.

Original language	English
Title of host publication	Women in Mathematical Biology
Subtitle of host publication	Research Collaboration Workshop, NIMBioS, Knoxville, June 2015
Editors	Anita Layton, Lura Miller
Publisher	Springer
ISBN (Print)	9783319603025
Publication status	Published - 20 Sept 2017

Publication series

Name	Association for Women in Mathematics Series
Publisher	Springer
ISSN (Print)	2364-5733

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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lenhart-lanzas2016_revised
The final publication is available at Springer via: http://www.springer.com/gb/book/9783319603025 Checked 9/1/2017
Accepted author manuscript, 917 KBLicence: None: All rights reserved

http://www.springer.com/gb/book/9783319603025

A systems biology approach to understanding and combating Clostridium difficile infection
Jabbari, S. (Principal Investigator)
Medical Research Council
1/10/12 → 31/05/14
Project: Research Councils

MRC Special Training in Biomedical Informatics Fellowship
Jabbari, S. (Recipient), 13 Jun 2011
Prize: Fellowship awarded competitively

Cite this

Jabbari, S., Fleming-Davies, A., Robertson, S. L., Asih, T. S. N., Lanzas, C., Lenhart, S., & Theriot, C. M. (2017). Mathematical modeling of the effects of nutrient competition and bile acid metabolism by the gut microbiota on colonization resistance against Clostridium difficile. In A. Layton, & L. Miller (Eds.), Women in Mathematical Biology: Research Collaboration Workshop, NIMBioS, Knoxville, June 2015 (Association for Women in Mathematics Series). Springer. http://www.springer.com/gb/book/9783319603025

Jabbari, Sara ; Fleming-Davies, Arietta ; Robertson, Suzanne L. et al. / Mathematical modeling of the effects of nutrient competition and bile acid metabolism by the gut microbiota on colonization resistance against Clostridium difficile. Women in Mathematical Biology: Research Collaboration Workshop, NIMBioS, Knoxville, June 2015. editor / Anita Layton ; Lura Miller. Springer, 2017. (Association for Women in Mathematics Series).

@inproceedings{7e36d58ae48142fca19391406cb0bb16,

title = "Mathematical modeling of the effects of nutrient competition and bile acid metabolism by the gut microbiota on colonization resistance against Clostridium difficile",

abstract = "Clostridium difficile is the leading cause of infectious diarrhea in hospitalsand one of the most common healthcare associated infections. Antibiotics alterthe normal gut microbiota and facilitate the colonization of enteric pathogens such as C. difficile. Our objective is to elucidate the role of bile acids and other mechanisms in providing colonization resistance against C. difficile. We formulated and analyzed differential equation models for microbial interactions in the gut and bile acid dynamics, as well as a combined model including both mechanisms. Our analysis indicates that bile acids do not prevent C. difficile colonization, but they regulate the onset of C. difficile colonization and growth after antibiotic perturbation. These results have implications in the development of novel ways to inhibit C. difficile infection.",

author = "Sara Jabbari and Arietta Fleming-Davies and Robertson, {Suzanne L.} and Asih, {Tri Sri Noor} and Cristina Lanzas and Suzanne Lenhart and Theriot, {Casey M.}",

year = "2017",

month = sep,

day = "20",

language = "English",

isbn = "9783319603025",

series = "Association for Women in Mathematics Series",

publisher = "Springer",

editor = "Anita Layton and Lura Miller",

booktitle = "Women in Mathematical Biology",

}

Jabbari, S, Fleming-Davies, A, Robertson, SL, Asih, TSN, Lanzas, C, Lenhart, S & Theriot, CM 2017, Mathematical modeling of the effects of nutrient competition and bile acid metabolism by the gut microbiota on colonization resistance against Clostridium difficile. in A Layton & L Miller (eds), Women in Mathematical Biology: Research Collaboration Workshop, NIMBioS, Knoxville, June 2015. Association for Women in Mathematics Series, Springer. <http://www.springer.com/gb/book/9783319603025>

Mathematical modeling of the effects of nutrient competition and bile acid metabolism by the gut microbiota on colonization resistance against Clostridium difficile. / Jabbari, Sara; Fleming-Davies, Arietta; Robertson, Suzanne L. et al.
Women in Mathematical Biology: Research Collaboration Workshop, NIMBioS, Knoxville, June 2015. ed. / Anita Layton; Lura Miller. Springer, 2017. (Association for Women in Mathematics Series).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Mathematical modeling of the effects of nutrient competition and bile acid metabolism by the gut microbiota on colonization resistance against Clostridium difficile

AU - Jabbari, Sara

AU - Fleming-Davies, Arietta

AU - Robertson, Suzanne L.

AU - Asih, Tri Sri Noor

AU - Lanzas, Cristina

AU - Lenhart, Suzanne

AU - Theriot, Casey M.

PY - 2017/9/20

Y1 - 2017/9/20

N2 - Clostridium difficile is the leading cause of infectious diarrhea in hospitalsand one of the most common healthcare associated infections. Antibiotics alterthe normal gut microbiota and facilitate the colonization of enteric pathogens such as C. difficile. Our objective is to elucidate the role of bile acids and other mechanisms in providing colonization resistance against C. difficile. We formulated and analyzed differential equation models for microbial interactions in the gut and bile acid dynamics, as well as a combined model including both mechanisms. Our analysis indicates that bile acids do not prevent C. difficile colonization, but they regulate the onset of C. difficile colonization and growth after antibiotic perturbation. These results have implications in the development of novel ways to inhibit C. difficile infection.

AB - Clostridium difficile is the leading cause of infectious diarrhea in hospitalsand one of the most common healthcare associated infections. Antibiotics alterthe normal gut microbiota and facilitate the colonization of enteric pathogens such as C. difficile. Our objective is to elucidate the role of bile acids and other mechanisms in providing colonization resistance against C. difficile. We formulated and analyzed differential equation models for microbial interactions in the gut and bile acid dynamics, as well as a combined model including both mechanisms. Our analysis indicates that bile acids do not prevent C. difficile colonization, but they regulate the onset of C. difficile colonization and growth after antibiotic perturbation. These results have implications in the development of novel ways to inhibit C. difficile infection.

M3 - Conference contribution

SN - 9783319603025

T3 - Association for Women in Mathematics Series

BT - Women in Mathematical Biology

A2 - Layton, Anita

A2 - Miller, Lura

PB - Springer

ER -

Jabbari S, Fleming-Davies A, Robertson SL, Asih TSN, Lanzas C, Lenhart S et al. Mathematical modeling of the effects of nutrient competition and bile acid metabolism by the gut microbiota on colonization resistance against Clostridium difficile. In Layton A, Miller L, editors, Women in Mathematical Biology: Research Collaboration Workshop, NIMBioS, Knoxville, June 2015. Springer. 2017. (Association for Women in Mathematics Series).

Mathematical modeling of the effects of nutrient competition and bile acid metabolism by the gut microbiota on colonization resistance against Clostridium difficile

Abstract

Publication series

UN SDGs

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Projects

A systems biology approach to understanding and combating Clostridium difficile infection

Prizes

MRC Special Training in Biomedical Informatics Fellowship

Cite this