Marked bone marrow eosinophilia at the time of relapse of acute myeloblastic leukaemia in association with the appearance of translocation t(12;20)(q24;q11)

F Partridge; W Richardson; P Kearns; R Wilcox; G Majumdar

doi:10.3109/10428199609051747

Marked bone marrow eosinophilia at the time of relapse of acute myeloblastic leukaemia in association with the appearance of translocation t(12;20)(q24;q11)

F Partridge, W Richardson, P Kearns, R Wilcox, G Majumdar

Cancer Clinical Trials Unit

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of acute myeloblastic leukaemia (AML), FAB type M2, with karyotype t(8;21)(q22;q22), who at the time of relapse showed marked eosinophilia of the bone marrow. Karyotype analysis showed the appearance of an additional clone t(8;21)(q22;q22),t(12;20)(q24;q11). To the best of our knowledge, marked eosinophilia has not been reported in association with this particular chromosomal translocation.

Original language	English
Pages (from-to)	181-2
Number of pages	2
Journal	Leukemia and Lymphoma
Volume	22
Issue number	1-2
DOIs	https://doi.org/10.3109/10428199609051747
Publication status	Published - Jun 1996

Keywords

Adult
Antineoplastic Combined Chemotherapy Protocols
Bone Marrow
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 8
Cytarabine
Daunorubicin
Eosinophilia
Etoposide
Humans
Idarubicin
Leukemia, Myeloid, Acute
Male
Neoplasm Recurrence, Local
Remission Induction
Translocation, Genetic

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title = "Marked bone marrow eosinophilia at the time of relapse of acute myeloblastic leukaemia in association with the appearance of translocation t(12;20)(q24;q11)",

abstract = "We report a case of acute myeloblastic leukaemia (AML), FAB type M2, with karyotype t(8;21)(q22;q22), who at the time of relapse showed marked eosinophilia of the bone marrow. Karyotype analysis showed the appearance of an additional clone t(8;21)(q22;q22),t(12;20)(q24;q11). To the best of our knowledge, marked eosinophilia has not been reported in association with this particular chromosomal translocation.",

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author = "F Partridge and W Richardson and P Kearns and R Wilcox and G Majumdar",

year = "1996",

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doi = "10.3109/10428199609051747",

language = "English",

volume = "22",

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T1 - Marked bone marrow eosinophilia at the time of relapse of acute myeloblastic leukaemia in association with the appearance of translocation t(12;20)(q24;q11)

AU - Partridge, F

AU - Richardson, W

AU - Kearns, P

AU - Wilcox, R

AU - Majumdar, G

PY - 1996/6

Y1 - 1996/6

N2 - We report a case of acute myeloblastic leukaemia (AML), FAB type M2, with karyotype t(8;21)(q22;q22), who at the time of relapse showed marked eosinophilia of the bone marrow. Karyotype analysis showed the appearance of an additional clone t(8;21)(q22;q22),t(12;20)(q24;q11). To the best of our knowledge, marked eosinophilia has not been reported in association with this particular chromosomal translocation.

AB - We report a case of acute myeloblastic leukaemia (AML), FAB type M2, with karyotype t(8;21)(q22;q22), who at the time of relapse showed marked eosinophilia of the bone marrow. Karyotype analysis showed the appearance of an additional clone t(8;21)(q22;q22),t(12;20)(q24;q11). To the best of our knowledge, marked eosinophilia has not been reported in association with this particular chromosomal translocation.

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KW - Antineoplastic Combined Chemotherapy Protocols

KW - Bone Marrow

KW - Chromosomes, Human, Pair 12

KW - Chromosomes, Human, Pair 20

KW - Chromosomes, Human, Pair 21

KW - Chromosomes, Human, Pair 8

KW - Cytarabine

KW - Daunorubicin

KW - Eosinophilia

KW - Etoposide

KW - Humans

KW - Idarubicin

KW - Leukemia, Myeloid, Acute

KW - Male

KW - Neoplasm Recurrence, Local

KW - Remission Induction

KW - Translocation, Genetic

U2 - 10.3109/10428199609051747

DO - 10.3109/10428199609051747

M3 - Article

C2 - 8724547

SN - 1042-8194

VL - 22

SP - 181

EP - 182

JO - Leukemia and Lymphoma

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IS - 1-2

ER -

Marked bone marrow eosinophilia at the time of relapse of acute myeloblastic leukaemia in association with the appearance of translocation t(12;20)(q24;q11)

Abstract

Keywords

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