TY - JOUR
T1 - Manipulation of the Renin Angiotensin System in Peripheral Arterial Disease
AU - Hobbs, Simon
AU - Thomas, Mark
AU - Bradbury, Andrew
PY - 2004/1/1
Y1 - 2004/1/1
N2 - The Heart Outcomes Prevention Evaluation (HOPE) study has provided evidence for the use of ramipril for secondary cardiac prevention for patients with peripheral arterial disease. Despite this many vascular surgeons and general practitioners are reluctant to prescribe ACE inhibitors in a group of patients perceived to have a high incidence of renal artery stenosis. This review aims to review the pathophysiology of the renin-angiotensin system and make evidence based recommendations for commencing ACE inhibitors as part of a comprehensive delivery of best medical therapy to patients with peripheral arterial disease.
AB - The Heart Outcomes Prevention Evaluation (HOPE) study has provided evidence for the use of ramipril for secondary cardiac prevention for patients with peripheral arterial disease. Despite this many vascular surgeons and general practitioners are reluctant to prescribe ACE inhibitors in a group of patients perceived to have a high incidence of renal artery stenosis. This review aims to review the pathophysiology of the renin-angiotensin system and make evidence based recommendations for commencing ACE inhibitors as part of a comprehensive delivery of best medical therapy to patients with peripheral arterial disease.
UR - http://www.scopus.com/inward/record.url?scp=7744235528&partnerID=8YFLogxK
U2 - 10.1016/j.ejvs.2004.08.003
DO - 10.1016/j.ejvs.2004.08.003
M3 - Review article
C2 - 15531190
VL - 28
SP - 573
EP - 582
JO - European Journal of Vascular and Endovascular Surgery
JF - European Journal of Vascular and Endovascular Surgery
ER -