Effective management of groundwater in and countries, such as Saudi Arabia, is an important factor in sustainable development. A regional numerical simulation model of a multi-aquifer system including the Dammam and Umm Er Radhuma (UER) aquifers was developed to assess the behaviour of the aquifer system under long-term water stresses. The model was utilized to predict the responses of the aquifer system under three alternative pumping schemes over a planning horizon of 31 years (1995-2025). Model results postulate that dewatering of the Dammam aquifer will occur at low productivity sites and along the outcrop with the current trend towards increasing abstraction. The UER will exhibit significant cones of depression at large irrigation projects. Aquifer dewatering and drawdowns will be minimal with the conservation alternative. This management scheme should be adopted for the future development ami protection of groundwater in the province.