MAIT cells are activated during human viral infections

Bonnie van Wilgenburg; Iris Scherwitzl; Edward C Hutchinson; Tianqi Leng; Ayako Kurioka; Corinna Kulicke; Catherine de Lara; Suzanne Cole; Sirijitt Vasanawathana; Wannee Limpitikul; Prida Malasit; Duncan Young; Laura Denney; Michael D Moore; Paolo Fabris; Maria Teresa Giordani; Ye Oo; Stephen M Laidlaw; Lynn B Dustin; Ling-Pei Ho; Fiona M Thompson; Narayan Ramamurthy; Juthathip Mongkolsapaya; Christian B Willberg; Gavin R Screaton; Paul Klenerman; STOP-HCV consortium

doi:10.1038/ncomms11653

MAIT cells are activated during human viral infections

Bonnie van Wilgenburg
, Iris Scherwitzl
, Edward C Hutchinson
, Tianqi Leng
, Ayako Kurioka
, Corinna Kulicke
, Catherine de Lara
, Suzanne Cole
, Sirijitt Vasanawathana
, Wannee Limpitikul
, Prida Malasit
, Duncan Young
, Laura Denney
, Michael D Moore
, Paolo Fabris
, Maria Teresa Giordani
, Ye Oo
, Stephen M Laidlaw
, Lynn B Dustin
, Ling-Pei Ho

Fiona M Thompson, Narayan Ramamurthy, Juthathip Mongkolsapaya, Christian B Willberg, Gavin R Screaton, Paul Klenerman, STOP-HCV consortium

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

220 Citations (Scopus)

223 Downloads (Pure)

Abstract

Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation-driving cytokine release and Granzyme B upregulation-is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activation correlate with disease severity in acute dengue infection. Furthermore, HCV treatment with interferon-α leads to specific MAIT cell activation in vivo in parallel with an enhanced therapeutic response. Moreover, TCR-independent activation of MAIT cells leads to a reduction of HCV replication in vitro mediated by IFN-γ. Together these data demonstrate MAIT cells are activated following viral infections, and suggest a potential role in both host defence and immunopathology.

Original language	English
Article number	11653
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms11653
Publication status	Published - 23 Jun 2016

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SDG 3 Good Health and Well-being

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Intrahepatic Signals Involve in the Recruitment and Differentiation of IL-17 Secreting T Cells and Regulatory T Cells in Chronic Hepatitis - Fellowship
Oo, Y. (Principal Investigator)
Medical Research Council
4/01/12 → 5/01/18
Project: Research Councils

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van Wilgenburg, B., Scherwitzl, I., Hutchinson, E. C., Leng, T., Kurioka, A., Kulicke, C., de Lara, C., Cole, S., Vasanawathana, S., Limpitikul, W., Malasit, P., Young, D., Denney, L., Moore, M. D., Fabris, P., Giordani, M. T., Oo, Y., Laidlaw, S. M., Dustin, L. B., ... STOP-HCV consortium (2016). MAIT cells are activated during human viral infections. Nature Communications, 7, Article 11653. https://doi.org/10.1038/ncomms11653

@article{ea97b366dd2a4b9ebfd974136829a6cd,

title = "MAIT cells are activated during human viral infections",

abstract = "Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation-driving cytokine release and Granzyme B upregulation-is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activation correlate with disease severity in acute dengue infection. Furthermore, HCV treatment with interferon-α leads to specific MAIT cell activation in vivo in parallel with an enhanced therapeutic response. Moreover, TCR-independent activation of MAIT cells leads to a reduction of HCV replication in vitro mediated by IFN-γ. Together these data demonstrate MAIT cells are activated following viral infections, and suggest a potential role in both host defence and immunopathology.",

author = "\{van Wilgenburg\}, Bonnie and Iris Scherwitzl and Hutchinson, \{Edward C\} and Tianqi Leng and Ayako Kurioka and Corinna Kulicke and \{de Lara\}, Catherine and Suzanne Cole and Sirijitt Vasanawathana and Wannee Limpitikul and Prida Malasit and Duncan Young and Laura Denney and Moore, \{Michael D\} and Paolo Fabris and Giordani, \{Maria Teresa\} and Ye Oo and Laidlaw, \{Stephen M\} and Dustin, \{Lynn B\} and Ling-Pei Ho and Thompson, \{Fiona M\} and Narayan Ramamurthy and Juthathip Mongkolsapaya and Willberg, \{Christian B\} and Screaton, \{Gavin R\} and Paul Klenerman and \{STOP-HCV consortium\}",

year = "2016",

month = jun,

day = "23",

doi = "10.1038/ncomms11653",

language = "English",

volume = "7",

journal = "Nature Communications",

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van Wilgenburg, B, Scherwitzl, I, Hutchinson, EC, Leng, T, Kurioka, A, Kulicke, C, de Lara, C, Cole, S, Vasanawathana, S, Limpitikul, W, Malasit, P, Young, D, Denney, L, Moore, MD, Fabris, P, Giordani, MT, Oo, Y, Laidlaw, SM, Dustin, LB, Ho, L-P, Thompson, FM, Ramamurthy, N, Mongkolsapaya, J, Willberg, CB, Screaton, GR, Klenerman, P & STOP-HCV consortium 2016, 'MAIT cells are activated during human viral infections', Nature Communications, vol. 7, 11653. https://doi.org/10.1038/ncomms11653

TY - JOUR

T1 - MAIT cells are activated during human viral infections

AU - van Wilgenburg, Bonnie

AU - Scherwitzl, Iris

AU - Hutchinson, Edward C

AU - Leng, Tianqi

AU - Kurioka, Ayako

AU - Kulicke, Corinna

AU - de Lara, Catherine

AU - Cole, Suzanne

AU - Vasanawathana, Sirijitt

AU - Limpitikul, Wannee

AU - Malasit, Prida

AU - Young, Duncan

AU - Denney, Laura

AU - Moore, Michael D

AU - Fabris, Paolo

AU - Giordani, Maria Teresa

AU - Oo, Ye

AU - Laidlaw, Stephen M

AU - Dustin, Lynn B

AU - Ho, Ling-Pei

AU - Thompson, Fiona M

AU - Ramamurthy, Narayan

AU - Mongkolsapaya, Juthathip

AU - Willberg, Christian B

AU - Screaton, Gavin R

AU - Klenerman, Paul

AU - STOP-HCV consortium

PY - 2016/6/23

Y1 - 2016/6/23

N2 - Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation-driving cytokine release and Granzyme B upregulation-is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activation correlate with disease severity in acute dengue infection. Furthermore, HCV treatment with interferon-α leads to specific MAIT cell activation in vivo in parallel with an enhanced therapeutic response. Moreover, TCR-independent activation of MAIT cells leads to a reduction of HCV replication in vitro mediated by IFN-γ. Together these data demonstrate MAIT cells are activated following viral infections, and suggest a potential role in both host defence and immunopathology.

AB - Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation-driving cytokine release and Granzyme B upregulation-is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activation correlate with disease severity in acute dengue infection. Furthermore, HCV treatment with interferon-α leads to specific MAIT cell activation in vivo in parallel with an enhanced therapeutic response. Moreover, TCR-independent activation of MAIT cells leads to a reduction of HCV replication in vitro mediated by IFN-γ. Together these data demonstrate MAIT cells are activated following viral infections, and suggest a potential role in both host defence and immunopathology.

UR - https://www.scopus.com/pages/publications/84975705227

U2 - 10.1038/ncomms11653

DO - 10.1038/ncomms11653

M3 - Article

C2 - 27337592

SN - 2041-1723

VL - 7

JO - Nature Communications

JF - Nature Communications

M1 - 11653

ER -

MAIT cells are activated during human viral infections

Abstract

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Intrahepatic Signals Involve in the Recruitment and Differentiation of IL-17 Secreting T Cells and Regulatory T Cells in Chronic Hepatitis - Fellowship

Cite this