Magnetic resonance spectroscopy in the assessment of pilocytic astrocytomas

Lisa M. Harris; Nigel P. Davies; Lesley Macpherson; Shaheen Lateef; Kal Natarajan; Marie-anne Brundler; Spyros Sgouros; Martin W. English; Theodoros N. Arvanitis; Richard G. Grundy; Andrew C. Peet

doi:10.1016/j.ejca.2008.08.012

Magnetic resonance spectroscopy in the assessment of pilocytic astrocytomas

Lisa M. Harris, Nigel P. Davies, Lesley Macpherson, Shaheen Lateef, Kal Natarajan, Marie-anne Brundler, Spyros Sgouros, Martin W. English, Theodoros N. Arvanitis, Richard G. Grundy, Andrew C. Peet

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

BACKGROUND: Pilocytic astrocytomas (PA) are common childhood brain tumours whose management and prognosis vary widely depending on location. (1)H magnetic resonance spectroscopy (MRS) measures biochemistry in vivo and shows promise for characterising brain tumours and aiding management. METHODS: Single voxel MRS (1.5 Tesla, TE 30 ms, TR 1500 ms) was performed on 27 children with PAs. Cases were designated 'progressors' if tumour progression led to their clinical management plan being altered. RESULTS: Prior to treatment, supratentorial tumours had significantly higher myo-inositol (p

Original language	English
Pages (from-to)	2640-2647
Number of pages	8
Journal	European Journal of Cancer
Volume	44
Issue number	17
DOIs	https://doi.org/10.1016/j.ejca.2008.08.012
Publication status	Published - 1 Nov 2008

Keywords

Magnetic resonance spectroscopy
Prognosis
Pilocytic astrocytomas
Myo-inositol

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10.1016/j.ejca.2008.08.012

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title = "Magnetic resonance spectroscopy in the assessment of pilocytic astrocytomas",

abstract = "BACKGROUND: Pilocytic astrocytomas (PA) are common childhood brain tumours whose management and prognosis vary widely depending on location. (1)H magnetic resonance spectroscopy (MRS) measures biochemistry in vivo and shows promise for characterising brain tumours and aiding management. METHODS: Single voxel MRS (1.5 Tesla, TE 30 ms, TR 1500 ms) was performed on 27 children with PAs. Cases were designated 'progressors' if tumour progression led to their clinical management plan being altered. RESULTS: Prior to treatment, supratentorial tumours had significantly higher myo-inositol (p",

keywords = "Magnetic resonance spectroscopy, Prognosis, Pilocytic astrocytomas, Myo-inositol",

author = "Harris, {Lisa M.} and Davies, {Nigel P.} and Lesley Macpherson and Shaheen Lateef and Kal Natarajan and Marie-anne Brundler and Spyros Sgouros and English, {Martin W.} and Arvanitis, {Theodoros N.} and Grundy, {Richard G.} and Peet, {Andrew C.}",

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doi = "10.1016/j.ejca.2008.08.012",

language = "English",

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TY - JOUR

T1 - Magnetic resonance spectroscopy in the assessment of pilocytic astrocytomas

AU - Harris, Lisa M.

AU - Davies, Nigel P.

AU - Macpherson, Lesley

AU - Lateef, Shaheen

AU - Natarajan, Kal

AU - Brundler, Marie-anne

AU - Sgouros, Spyros

AU - English, Martin W.

AU - Arvanitis, Theodoros N.

AU - Grundy, Richard G.

AU - Peet, Andrew C.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - BACKGROUND: Pilocytic astrocytomas (PA) are common childhood brain tumours whose management and prognosis vary widely depending on location. (1)H magnetic resonance spectroscopy (MRS) measures biochemistry in vivo and shows promise for characterising brain tumours and aiding management. METHODS: Single voxel MRS (1.5 Tesla, TE 30 ms, TR 1500 ms) was performed on 27 children with PAs. Cases were designated 'progressors' if tumour progression led to their clinical management plan being altered. RESULTS: Prior to treatment, supratentorial tumours had significantly higher myo-inositol (p

AB - BACKGROUND: Pilocytic astrocytomas (PA) are common childhood brain tumours whose management and prognosis vary widely depending on location. (1)H magnetic resonance spectroscopy (MRS) measures biochemistry in vivo and shows promise for characterising brain tumours and aiding management. METHODS: Single voxel MRS (1.5 Tesla, TE 30 ms, TR 1500 ms) was performed on 27 children with PAs. Cases were designated 'progressors' if tumour progression led to their clinical management plan being altered. RESULTS: Prior to treatment, supratentorial tumours had significantly higher myo-inositol (p

KW - Magnetic resonance spectroscopy

KW - Prognosis

KW - Pilocytic astrocytomas

KW - Myo-inositol

U2 - 10.1016/j.ejca.2008.08.012

DO - 10.1016/j.ejca.2008.08.012

M3 - Article

C2 - 18835152

SN - 1879-0852

SN - 1879-2995

VL - 44

SP - 2640

EP - 2647

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 17

ER -

Magnetic resonance spectroscopy in the assessment of pilocytic astrocytomas

Abstract

Keywords

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