Magnetic resonance spectroscopy in the assessment of pilocytic astrocytomas

Lisa M. Harris, Nigel P. Davies, Lesley Macpherson, Shaheen Lateef, Kal Natarajan, Marie-anne Brundler, Spyros Sgouros, Martin W. English, Theodoros N. Arvanitis, Richard G. Grundy, Andrew C. Peet

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


BACKGROUND: Pilocytic astrocytomas (PA) are common childhood brain tumours whose management and prognosis vary widely depending on location. (1)H magnetic resonance spectroscopy (MRS) measures biochemistry in vivo and shows promise for characterising brain tumours and aiding management. METHODS: Single voxel MRS (1.5 Tesla, TE 30 ms, TR 1500 ms) was performed on 27 children with PAs. Cases were designated 'progressors' if tumour progression led to their clinical management plan being altered. RESULTS: Prior to treatment, supratentorial tumours had significantly higher myo-inositol (p
Original languageEnglish
Pages (from-to)2640-2647
Number of pages8
JournalEuropean Journal of Cancer
Issue number17
Publication statusPublished - 1 Nov 2008


  • Magnetic resonance spectroscopy
  • Prognosis
  • Pilocytic astrocytomas
  • Myo-inositol


Dive into the research topics of 'Magnetic resonance spectroscopy in the assessment of pilocytic astrocytomas'. Together they form a unique fingerprint.

Cite this