Magnetic resonance imaging based functional imaging in paediatric oncology

Karen A Manias, Simrandip K Gill, Lesley MacPherson, Katharine Foster, Adam Oates, Andrew C Peet

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Imaging is central to management of solid tumours in children. Conventional magnetic resonance imaging (MRI) is the standard imaging modality for tumours of the central nervous system (CNS) and limbs and is increasingly used in the abdomen. It provides excellent structural detail, but imparts limited information about tumour type, aggressiveness, metastatic potential or early treatment response. MRI based functional imaging techniques, such as magnetic resonance spectroscopy, diffusion and perfusion weighted imaging, probe tissue properties to provide clinically important information about metabolites, structure and blood flow. This review describes the role of and evidence behind these functional imaging techniques in paediatric oncology and implications for integrating them into routine clinical practice.

Original languageEnglish
Pages (from-to)251-265
Number of pages15
JournalEuropean Journal of Cancer
Publication statusPublished - Feb 2017


  • Biomarkers, Tumor
  • Central Nervous System Neoplasms
  • Child
  • Diffusion Magnetic Resonance Imaging
  • Humans
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Neoplasms
  • Journal Article
  • Review
  • Research Support, Non-U.S. Gov't


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