Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA

Jean-Louis H. A. Duprey, James Carr-Smith, Sarah L. Horswell, Jarosław Kowalski, James H. R. Tucker

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)
358 Downloads (Pure)

Abstract

The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.

Original languageEnglish
Pages (from-to)746-749
JournalJournal of the American Chemical Society
Volume138
Issue number3
Early online date22 Dec 2015
DOIs
Publication statusPublished - 15 Jan 2016

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