Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA

Jean-Louis H. A. Duprey; James Carr-Smith; Sarah L. Horswell; Jarosław Kowalski; James H. R. Tucker

doi:10.1021/jacs.5b11319

Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA

Jean-Louis H. A. Duprey, James Carr-Smith, Sarah L. Horswell, Jarosław Kowalski, James H. R. Tucker

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Abstract

The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.

Original language	English
Pages (from-to)	746-749
Journal	Journal of the American Chemical Society
Volume	138
Issue number	3
Early online date	22 Dec 2015
DOIs	https://doi.org/10.1021/jacs.5b11319
Publication status	Published - 15 Jan 2016

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10.1021/jacs.5b11319Licence: None: All rights reserved

Duprey_et_al_Macrocyclic_Metal_Complex_Journal_American_Chemical_Society
Final version of record published as: Duprey, Jean-Louis HA, et al. "Macrocylic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA." Journal of the American Chemical Society (2015). Available online: http://dx.doi.org/10.1021/jacs.5b11319 Checked Jan 2016
Accepted author manuscript, 1.64 MBLicence: None: All rights reserved

https://doi.org/10.1021/jacs.5b11319Licence: None: All rights reserved

Functional DNA-based assemblies
Tucker, J.
Engineering & Physical Science Research Council
16/03/09 → 31/03/14
Project: Research Councils

Cite this

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title = "Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA",

abstract = "The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.",

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AU - Kowalski, Jarosław

AU - Tucker, James H. R.

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AB - The direct incorporation of macrocyclic cyclidene complexes into DNA via automated synthesis results in a new family of metal-functionalized DNA derivatives that readily demonstrate their utility through the ability of one redox-active copper(II)-containing strand to distinguish electrochemically between all four canonical DNA nucleobases at a single site within a target sequence of DNA.

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Macrocyclic Metal Complex-DNA Conjugates for Electrochemical Sensing of Single Nucleobase Changes in DNA

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Functional DNA-based assemblies

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