Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses

Peter Lane; MY Kim; David Withers; Fabrina Gaspal; Vasileios Bekiaris; Guillaume Desanti; Mahmood Khan; Fiona McConnell; Graham Anderson

doi:10.1016/j.smim.2008.02.002

Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses

Peter Lane, MY Kim, David Withers, Fabrina Gaspal, Vasileios Bekiaris, Guillaume Desanti, Mahmood Khan, Fiona McConnell, Graham Anderson

Immunology and Immunotherapy

Research output: Contribution to journal › Article

18 Citations (Scopus)

Abstract

Lymphoid tissue inducer cells (LTi) are known for their role in embryonic lymphoid tissue development. We have identified LTi in adult tissues including spleen and thymus, and provide evidence here for their presence in the submucosa of the intestine. From these observations it is clear that LTi play multiple roles in the adaptive immune system, notably the ability to recruit and sustain primed CD4 T cells in environments where they provide help to other cells. We speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells.

Original language	English
Pages (from-to)	159-63
Number of pages	5
Journal	Seminars in Immunology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.smim.2008.02.002
Publication status	Published - 1 Jun 2008

Keywords

AIDS
CD4 memory
lymphoid tissue organization
HIV

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.smim.2008.02.002

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title = "Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses",

abstract = "Lymphoid tissue inducer cells (LTi) are known for their role in embryonic lymphoid tissue development. We have identified LTi in adult tissues including spleen and thymus, and provide evidence here for their presence in the submucosa of the intestine. From these observations it is clear that LTi play multiple roles in the adaptive immune system, notably the ability to recruit and sustain primed CD4 T cells in environments where they provide help to other cells. We speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells.",

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T1 - Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses

AU - Lane, Peter

AU - Kim, MY

AU - Withers, David

AU - Gaspal, Fabrina

AU - Bekiaris, Vasileios

AU - Desanti, Guillaume

AU - Khan, Mahmood

AU - McConnell, Fiona

AU - Anderson, Graham

PY - 2008/6/1

Y1 - 2008/6/1

N2 - Lymphoid tissue inducer cells (LTi) are known for their role in embryonic lymphoid tissue development. We have identified LTi in adult tissues including spleen and thymus, and provide evidence here for their presence in the submucosa of the intestine. From these observations it is clear that LTi play multiple roles in the adaptive immune system, notably the ability to recruit and sustain primed CD4 T cells in environments where they provide help to other cells. We speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells.

AB - Lymphoid tissue inducer cells (LTi) are known for their role in embryonic lymphoid tissue development. We have identified LTi in adult tissues including spleen and thymus, and provide evidence here for their presence in the submucosa of the intestine. From these observations it is clear that LTi play multiple roles in the adaptive immune system, notably the ability to recruit and sustain primed CD4 T cells in environments where they provide help to other cells. We speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells.

KW - AIDS

KW - CD4 memory

KW - lymphoid tissue organization

KW - HIV

U2 - 10.1016/j.smim.2008.02.002

DO - 10.1016/j.smim.2008.02.002

M3 - Article

C2 - 18407516

VL - 20

SP - 159

EP - 163

JO - Seminars in Immunology

JF - Seminars in Immunology

IS - 3

ER -

Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses

Abstract

Keywords

UN SDGs

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