Lymph node fibroblastic reticular cells in health and disease

Anne L Fletcher; Sophie E Acton; Konstantin Knoblich

doi:10.1038/nri3846

Lymph node fibroblastic reticular cells in health and disease

Anne L Fletcher, Sophie E Acton, Konstantin Knoblich

Immunology and Immunotherapy

Research output: Contribution to journal › Review article › peer-review

154 Citations (Scopus)

Abstract

Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs) — immunologically specialized myofibroblasts found in lymphoid tissue — has promoted these cells from benign bystanders to major players in the immune response. In this Review, we focus on recent advances regarding the immunobiology of lymph node-derived FRCs, presenting an updated view of crucial checkpoints during their development and their dynamic control of lymph node expansion and contraction during infection. We highlight the robust effects of FRCs on systemic B cell and T cell responses, and we present an emerging view of FRCs as drivers of pathology following acute and chronic viral infections. Lastly, we review emerging therapeutic advances that harness the immunoregulatory properties of FRCs.

Original language	English
Pages (from-to)	350-61
Number of pages	12
Journal	Nature Reviews Immunology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1038/nri3846
Publication status	Published - Jun 2015

Keywords

Animals
B-Lymphocytes
Cell Communication
Cell Movement
Cell Proliferation
Dendritic Cells, Follicular
Humans
Immune Tolerance
Infection
Lymph Nodes
Lymphoid Tissue
Models, Immunological
Myofibroblasts
T-Lymphocytes
Virus Diseases

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title = "Lymph node fibroblastic reticular cells in health and disease",

abstract = "Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs) — immunologically specialized myofibroblasts found in lymphoid tissue — has promoted these cells from benign bystanders to major players in the immune response. In this Review, we focus on recent advances regarding the immunobiology of lymph node-derived FRCs, presenting an updated view of crucial checkpoints during their development and their dynamic control of lymph node expansion and contraction during infection. We highlight the robust effects of FRCs on systemic B cell and T cell responses, and we present an emerging view of FRCs as drivers of pathology following acute and chronic viral infections. Lastly, we review emerging therapeutic advances that harness the immunoregulatory properties of FRCs.",

keywords = "Animals, B-Lymphocytes, Cell Communication, Cell Movement, Cell Proliferation, Dendritic Cells, Follicular, Humans, Immune Tolerance, Infection, Lymph Nodes, Lymphoid Tissue, Models, Immunological, Myofibroblasts, T-Lymphocytes, Virus Diseases",

author = "Fletcher, {Anne L} and Acton, {Sophie E} and Konstantin Knoblich",

year = "2015",

month = jun,

doi = "10.1038/nri3846",

language = "English",

volume = "15",

pages = "350--61",

journal = "Nature Reviews Immunology",

issn = "1474-1733",

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T1 - Lymph node fibroblastic reticular cells in health and disease

AU - Fletcher, Anne L

AU - Acton, Sophie E

AU - Knoblich, Konstantin

PY - 2015/6

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N2 - Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs) — immunologically specialized myofibroblasts found in lymphoid tissue — has promoted these cells from benign bystanders to major players in the immune response. In this Review, we focus on recent advances regarding the immunobiology of lymph node-derived FRCs, presenting an updated view of crucial checkpoints during their development and their dynamic control of lymph node expansion and contraction during infection. We highlight the robust effects of FRCs on systemic B cell and T cell responses, and we present an emerging view of FRCs as drivers of pathology following acute and chronic viral infections. Lastly, we review emerging therapeutic advances that harness the immunoregulatory properties of FRCs.

AB - Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs) — immunologically specialized myofibroblasts found in lymphoid tissue — has promoted these cells from benign bystanders to major players in the immune response. In this Review, we focus on recent advances regarding the immunobiology of lymph node-derived FRCs, presenting an updated view of crucial checkpoints during their development and their dynamic control of lymph node expansion and contraction during infection. We highlight the robust effects of FRCs on systemic B cell and T cell responses, and we present an emerging view of FRCs as drivers of pathology following acute and chronic viral infections. Lastly, we review emerging therapeutic advances that harness the immunoregulatory properties of FRCs.

KW - Animals

KW - B-Lymphocytes

KW - Cell Communication

KW - Cell Movement

KW - Cell Proliferation

KW - Dendritic Cells, Follicular

KW - Humans

KW - Immune Tolerance

KW - Infection

KW - Lymph Nodes

KW - Lymphoid Tissue

KW - Models, Immunological

KW - Myofibroblasts

KW - T-Lymphocytes

KW - Virus Diseases

U2 - 10.1038/nri3846

DO - 10.1038/nri3846

M3 - Review article

C2 - 25998961

SN - 1474-1733

VL - 15

SP - 350

EP - 361

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

IS - 6

ER -

Lymph node fibroblastic reticular cells in health and disease

Abstract

Keywords

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