Lymph node fibroblastic reticular cells in health and disease

Anne L Fletcher, Sophie E Acton, Konstantin Knoblich

Research output: Contribution to journalReview articlepeer-review

154 Citations (Scopus)


Over the past decade, a series of discoveries relating to fibroblastic reticular cells (FRCs) — immunologically specialized myofibroblasts found in lymphoid tissue — has promoted these cells from benign bystanders to major players in the immune response. In this Review, we focus on recent advances regarding the immunobiology of lymph node-derived FRCs, presenting an updated view of crucial checkpoints during their development and their dynamic control of lymph node expansion and contraction during infection. We highlight the robust effects of FRCs on systemic B cell and T cell responses, and we present an emerging view of FRCs as drivers of pathology following acute and chronic viral infections. Lastly, we review emerging therapeutic advances that harness the immunoregulatory properties of FRCs.

Original languageEnglish
Pages (from-to)350-61
Number of pages12
JournalNature Reviews Immunology
Issue number6
Publication statusPublished - Jun 2015


  • Animals
  • B-Lymphocytes
  • Cell Communication
  • Cell Movement
  • Cell Proliferation
  • Dendritic Cells, Follicular
  • Humans
  • Immune Tolerance
  • Infection
  • Lymph Nodes
  • Lymphoid Tissue
  • Models, Immunological
  • Myofibroblasts
  • T-Lymphocytes
  • Virus Diseases


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