Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

Qibo Zhang; Linda Bagrade; Jolanta Bernatoniene; Ed Clarke; James C Paton; Tim J Mitchell; Desmond A Nunez; Adam Finn

doi:10.1086/512617

Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

Qibo Zhang
, Linda Bagrade
, Jolanta Bernatoniene
, Ed Clarke
, James C Paton
, Tim J Mitchell
, Desmond A Nunez
, Adam Finn

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.

Original language	English
Pages (from-to)	1194-202
Number of pages	9
Journal	The Journal of Infectious Diseases
Volume	195
Issue number	8
DOIs	https://doi.org/10.1086/512617
Publication status	Published - 15 Apr 2007

Keywords

Antibodies, Bacterial
Bacterial Proteins
CD4-Positive T-Lymphocytes
Carrier State
Cell Proliferation
Cells, Cultured
Child
Child, Preschool
Female
Humans
Interferon-gamma
Male
Nasopharynx
Pneumococcal Infections
Streptococcus pneumoniae
Streptolysins
Time Factors
Toll-Like Receptors
Tumor Necrosis Factor-alpha

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10.1086/512617

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@article{ea4740116a4145d899e6f7631b016cc0,

title = "Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children",

abstract = "Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.",

keywords = "Antibodies, Bacterial, Bacterial Proteins, CD4-Positive T-Lymphocytes, Carrier State, Cell Proliferation, Cells, Cultured, Child, Child, Preschool, Female, Humans, Interferon-gamma, Male, Nasopharynx, Pneumococcal Infections, Streptococcus pneumoniae, Streptolysins, Time Factors, Toll-Like Receptors, Tumor Necrosis Factor-alpha",

author = "Qibo Zhang and Linda Bagrade and Jolanta Bernatoniene and Ed Clarke and Paton, \{James C\} and Mitchell, \{Tim J\} and Nunez, \{Desmond A\} and Adam Finn",

year = "2007",

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day = "15",

doi = "10.1086/512617",

language = "English",

volume = "195",

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journal = "The Journal of Infectious Diseases",

issn = "0022-1899",

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T1 - Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

AU - Zhang, Qibo

AU - Bagrade, Linda

AU - Bernatoniene, Jolanta

AU - Clarke, Ed

AU - Paton, James C

AU - Mitchell, Tim J

AU - Nunez, Desmond A

AU - Finn, Adam

PY - 2007/4/15

Y1 - 2007/4/15

N2 - Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.

AB - Recent studies in mice have suggested that T cell immunity may be protective against pneumococcal infection.

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KW - Bacterial Proteins

KW - CD4-Positive T-Lymphocytes

KW - Carrier State

KW - Cell Proliferation

KW - Cells, Cultured

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Interferon-gamma

KW - Male

KW - Nasopharynx

KW - Pneumococcal Infections

KW - Streptococcus pneumoniae

KW - Streptolysins

KW - Time Factors

KW - Toll-Like Receptors

KW - Tumor Necrosis Factor-alpha

U2 - 10.1086/512617

DO - 10.1086/512617

M3 - Article

C2 - 17357058

SN - 0022-1899

VL - 195

SP - 1194

EP - 1202

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 8

ER -

Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children

Abstract

Keywords

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