Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference

Dominik Linz; Jason G Andrade; Elena Arbelo; Giuseppe Boriani; Guenter Breithardt; A John Camm; Valeria Caso; Jens Cosedis Nielsen; Mirko De Melis; Tom De Potter; Wolfgang Dichtl; Søren Zoega Diederichsen; Dobromir Dobrev; Nicolas Doll; David Duncker; Elke Dworatzek; Lars Eckardt; Christoph Eisert; Larissa Fabritz; Michal Farkowski; David Filgueiras-Rama; Andreas Goette; Eduard Guasch; Guido Hack; Stéphane Hatem; Karl Georg Haeusler; Jeff S Healey; Hein Heidbuechel; Ziad Hijazi; Lucas H Hofmeister; Leif Hove-Madsen; Thomas Huebner; Stefan Kääb; Dipak Kotecha; Katarzyna Malaczynska-Rajpold; José Luis Merino; Andreas Metzner; Lluís Mont; Ghulam Andre Ng; Michael Oeff; Abdul Shokor Parwani; Helmut Puererfellner; Ursula Ravens; Michiel Rienstra; Prashanthan Sanders; Daniel Scherr; Renate Schnabel; Ulrich Schotten; Christian Sohns; Gerhard Steinbeck; Daniel Steven; Tobias Toennis; Stylianos Tzeis; Isabelle C van Gelder; Roderick H van Leerdam; Kevin Vernooy; Manish Wadhwa; Reza Wakili; Stephan Willems; Henning Witt; Stef Zeemering; Paulus Kirchhof

doi:10.1093/europace/euae070

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference

Dominik Linz, Jason G Andrade, Elena Arbelo, Giuseppe Boriani, Guenter Breithardt, A John Camm, Valeria Caso, Jens Cosedis Nielsen, Mirko De Melis, Tom De Potter, Wolfgang Dichtl, Søren Zoega Diederichsen, Dobromir Dobrev, Nicolas Doll, David Duncker, Elke Dworatzek, Lars Eckardt, Christoph Eisert, Larissa Fabritz, Michal FarkowskiDavid Filgueiras-Rama, Andreas Goette, Eduard Guasch, Guido Hack, Stéphane Hatem, Karl Georg Haeusler, Jeff S Healey, Hein Heidbuechel, Ziad Hijazi, Lucas H Hofmeister, Leif Hove-Madsen, Thomas Huebner, Stefan Kääb, Dipak Kotecha, Katarzyna Malaczynska-Rajpold, José Luis Merino, Andreas Metzner, Lluís Mont, Ghulam Andre Ng, Michael Oeff, Abdul Shokor Parwani, Helmut Puererfellner, Ursula Ravens, Michiel Rienstra, Prashanthan Sanders, Daniel Scherr, Renate Schnabel, Ulrich Schotten, Christian Sohns, Gerhard Steinbeck, Daniel Steven, Tobias Toennis, Stylianos Tzeis, Isabelle C van Gelder, Roderick H van Leerdam, Kevin Vernooy, Manish Wadhwa, Reza Wakili, Stephan Willems, Henning Witt, Stef Zeemering, Paulus Kirchhof^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF.

Original language	English
Article number	euae070
Journal	Europace
Volume	26
Issue number	4
DOIs	https://doi.org/10.1093/europace/euae070
Publication status	Published - 9 Apr 2024

Bibliographical note

Funding
The 9th AFNET/EHRA consensus conference was co-financed by AFNET, EHRA, and the MAESTRIA consortium (EU grant agreement ID: 965286). Industry participants paid an attendance fee for the conference and provided an industry perspective during the discussions at the meeting but had no involvement in the writing process.

Keywords

Consensus statement
EHRA
Heart failure
Rhythm management
Research priorities
Quality of care
Stroke
Cognitive function
Screening
Dementia
Artificial intelligence
Cost
Atrial cardiomyopathy
Integrated care
Biomarkers
Technology
Research
AFNET
Outcomes
Atrial fibrillation
Guidelines
Anticoagulation
Catheter ablation
Bleeding

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10.1093/europace/euae070Licence: Creative Commons: Attribution-NonCommercial (CC BY-NC)

LinzD2024LongerFinal published version, 2.8 MBLicence: Creative Commons: Attribution-NonCommercial (CC BY-NC)

MAESTRIA: Machine Learning Artificial Intelligence Early Detection Stroke Atrial Fibrillation
Kirchhof, P. (Researcher), Gkoutos, G. (Principal Investigator) & Fabritz, L. (Researcher)
European Commission
1/03/21 → 28/02/26
Project: EU

Cite this

Linz, D., Andrade, J. G., Arbelo, E., Boriani, G., Breithardt, G., Camm, A. J., Caso, V., Nielsen, J. C., De Melis, M., De Potter, T., Dichtl, W., Diederichsen, S. Z., Dobrev, D., Doll, N., Duncker, D., Dworatzek, E., Eckardt, L., Eisert, C., Fabritz, L., ... Kirchhof, P. (2024). Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference. Europace, 26(4), Article euae070. https://doi.org/10.1093/europace/euae070

@article{66a3b0b2f50e461b9d1778d193ec4ae9,

title = "Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference",

abstract = "Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in M{\"u}nster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF.",

keywords = "Consensus statement, EHRA, Heart failure, Rhythm management, Research priorities, Quality of care, Stroke, Cognitive function, Screening, Dementia, Artificial intelligence, Cost, Atrial cardiomyopathy, Integrated care, Biomarkers, Technology, Research, AFNET, Outcomes, Atrial fibrillation, Guidelines, Anticoagulation, Catheter ablation, Bleeding",

author = "Dominik Linz and Andrade, {Jason G} and Elena Arbelo and Giuseppe Boriani and Guenter Breithardt and Camm, {A John} and Valeria Caso and Nielsen, {Jens Cosedis} and {De Melis}, Mirko and {De Potter}, Tom and Wolfgang Dichtl and Diederichsen, {S{\o}ren Zoega} and Dobromir Dobrev and Nicolas Doll and David Duncker and Elke Dworatzek and Lars Eckardt and Christoph Eisert and Larissa Fabritz and Michal Farkowski and David Filgueiras-Rama and Andreas Goette and Eduard Guasch and Guido Hack and St{\'e}phane Hatem and Haeusler, {Karl Georg} and Healey, {Jeff S} and Hein Heidbuechel and Ziad Hijazi and Hofmeister, {Lucas H} and Leif Hove-Madsen and Thomas Huebner and Stefan K{\"a}{\"a}b and Dipak Kotecha and Katarzyna Malaczynska-Rajpold and Merino, {Jos{\'e} Luis} and Andreas Metzner and Llu{\'i}s Mont and Ng, {Ghulam Andre} and Michael Oeff and Parwani, {Abdul Shokor} and Helmut Puererfellner and Ursula Ravens and Michiel Rienstra and Prashanthan Sanders and Daniel Scherr and Renate Schnabel and Ulrich Schotten and Christian Sohns and Gerhard Steinbeck and Daniel Steven and Tobias Toennis and Stylianos Tzeis and {van Gelder}, {Isabelle C} and {van Leerdam}, {Roderick H} and Kevin Vernooy and Manish Wadhwa and Reza Wakili and Stephan Willems and Henning Witt and Stef Zeemering and Paulus Kirchhof",

note = "Funding The 9th AFNET/EHRA consensus conference was co-financed by AFNET, EHRA, and the MAESTRIA consortium (EU grant agreement ID: 965286). Industry participants paid an attendance fee for the conference and provided an industry perspective during the discussions at the meeting but had no involvement in the writing process.",

year = "2024",

month = apr,

day = "9",

doi = "10.1093/europace/euae070",

language = "English",

volume = "26",

journal = "Europace",

issn = "1099-5129",

publisher = "Oxford University Press",

number = "4",

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Linz, D, Andrade, JG, Arbelo, E, Boriani, G, Breithardt, G, Camm, AJ, Caso, V, Nielsen, JC, De Melis, M, De Potter, T, Dichtl, W, Diederichsen, SZ, Dobrev, D, Doll, N, Duncker, D, Dworatzek, E, Eckardt, L, Eisert, C, Fabritz, L, Farkowski, M, Filgueiras-Rama, D, Goette, A, Guasch, E, Hack, G, Hatem, S, Haeusler, KG, Healey, JS, Heidbuechel, H, Hijazi, Z, Hofmeister, LH, Hove-Madsen, L, Huebner, T, Kääb, S, Kotecha, D, Malaczynska-Rajpold, K, Merino, JL, Metzner, A, Mont, L, Ng, GA, Oeff, M, Parwani, AS, Puererfellner, H, Ravens, U, Rienstra, M, Sanders, P, Scherr, D, Schnabel, R, Schotten, U, Sohns, C, Steinbeck, G, Steven, D, Toennis, T, Tzeis, S, van Gelder, IC, van Leerdam, RH, Vernooy, K, Wadhwa, M, Wakili, R, Willems, S, Witt, H, Zeemering, S & Kirchhof, P 2024, 'Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference', Europace, vol. 26, no. 4, euae070. https://doi.org/10.1093/europace/euae070

TY - JOUR

T1 - Longer and better lives for patients with atrial fibrillation

T2 - the 9th AFNET/EHRA consensus conference

AU - Linz, Dominik

AU - Andrade, Jason G

AU - Arbelo, Elena

AU - Boriani, Giuseppe

AU - Breithardt, Guenter

AU - Camm, A John

AU - Caso, Valeria

AU - Nielsen, Jens Cosedis

AU - De Melis, Mirko

AU - De Potter, Tom

AU - Dichtl, Wolfgang

AU - Diederichsen, Søren Zoega

AU - Dobrev, Dobromir

AU - Doll, Nicolas

AU - Duncker, David

AU - Dworatzek, Elke

AU - Eckardt, Lars

AU - Eisert, Christoph

AU - Fabritz, Larissa

AU - Farkowski, Michal

AU - Filgueiras-Rama, David

AU - Goette, Andreas

AU - Guasch, Eduard

AU - Hack, Guido

AU - Hatem, Stéphane

AU - Haeusler, Karl Georg

AU - Healey, Jeff S

AU - Heidbuechel, Hein

AU - Hijazi, Ziad

AU - Hofmeister, Lucas H

AU - Hove-Madsen, Leif

AU - Huebner, Thomas

AU - Kääb, Stefan

AU - Kotecha, Dipak

AU - Malaczynska-Rajpold, Katarzyna

AU - Merino, José Luis

AU - Metzner, Andreas

AU - Mont, Lluís

AU - Ng, Ghulam Andre

AU - Oeff, Michael

AU - Parwani, Abdul Shokor

AU - Puererfellner, Helmut

AU - Ravens, Ursula

AU - Rienstra, Michiel

AU - Sanders, Prashanthan

AU - Scherr, Daniel

AU - Schnabel, Renate

AU - Schotten, Ulrich

AU - Sohns, Christian

AU - Steinbeck, Gerhard

AU - Steven, Daniel

AU - Toennis, Tobias

AU - Tzeis, Stylianos

AU - van Gelder, Isabelle C

AU - van Leerdam, Roderick H

AU - Vernooy, Kevin

AU - Wadhwa, Manish

AU - Wakili, Reza

AU - Willems, Stephan

AU - Witt, Henning

AU - Zeemering, Stef

AU - Kirchhof, Paulus

N1 - Funding The 9th AFNET/EHRA consensus conference was co-financed by AFNET, EHRA, and the MAESTRIA consortium (EU grant agreement ID: 965286). Industry participants paid an attendance fee for the conference and provided an industry perspective during the discussions at the meeting but had no involvement in the writing process.

PY - 2024/4/9

Y1 - 2024/4/9

N2 - Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF.

AB - Aims: Recent trial data demonstrate beneficial effects of active rhythm management in patients with atrial fibrillation (AF) and support the concept that a low arrhythmia burden is associated with a low risk of AF-related complications. The aim of this document is to summarize the key outcomes of the 9th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Methods and results: Eighty-three international experts met in Münster for 2 days in September 2023. Key findings are as follows: (i) Active rhythm management should be part of the default initial treatment for all suitable patients with AF. (ii) Patients with device-detected AF have a low burden of AF and a low risk of stroke. Anticoagulation prevents some strokes and also increases major but non-lethal bleeding. (iii) More research is needed to improve stroke risk prediction in patients with AF, especially in those with a low AF burden. Biomolecules, genetics, and imaging can support this. (iv) The presence of AF should trigger systematic workup and comprehensive treatment of concomitant cardiovascular conditions. (v) Machine learning algorithms have been used to improve detection or likely development of AF. Cooperation between clinicians and data scientists is needed to leverage the potential of data science applications for patients with AF. Conclusions: Patients with AF and a low arrhythmia burden have a lower risk of stroke and other cardiovascular events than those with a high arrhythmia burden. Combining active rhythm control, anticoagulation, rate control, and therapy of concomitant cardiovascular conditions can improve the lives of patients with AF.

KW - Consensus statement

KW - EHRA

KW - Heart failure

KW - Rhythm management

KW - Research priorities

KW - Quality of care

KW - Stroke

KW - Cognitive function

KW - Screening

KW - Dementia

KW - Artificial intelligence

KW - Cost

KW - Atrial cardiomyopathy

KW - Integrated care

KW - Biomarkers

KW - Technology

KW - Research

KW - AFNET

KW - Outcomes

KW - Atrial fibrillation

KW - Guidelines

KW - Anticoagulation

KW - Catheter ablation

KW - Bleeding

U2 - 10.1093/europace/euae070

DO - 10.1093/europace/euae070

M3 - Article

SN - 1099-5129

VL - 26

JO - Europace

JF - Europace

IS - 4

M1 - euae070

ER -

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference

Abstract

Bibliographical note

Keywords

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Projects

MAESTRIA: Machine Learning Artificial Intelligence Early Detection Stroke Atrial Fibrillation

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