TY - JOUR
T1 - Long-term release of antibiotics by carbon nanotube-coated titanium alloy 2 surfaces diminish biofilm formation by Staphylococcus epidermidis
AU - Hirschfeld, Josefine
AU - Akinoglu, Eser M
AU - Wirtz, Dieter C
AU - Hoerauf, Achim
AU - Bekeredjian-Ding, Isabelle
AU - Jepsen, Soren
AU - Haddouti, El-Mustapha
AU - Limmer, Andreas
AU - Giersig, Michael
PY - 2017/5
Y1 - 2017/5
N2 - Bacterial biofilms cause a considerable amount of prosthetic joint infections every year, resulting in morbidity and expensive revision surgery. To address this problem, surface modifications of implant materials such as carbon nanotube (CNT) coatings have been investigated in the past years. CNTs are biologically compatible and can be utilized as drug delivery systems. In this study, multi-walled carbon nanotube (MWCNT) coated TiAl6V4 titanium alloy discs were fabricated and impregnated with Rifampicin, and tested for their ability to prevent biofilm formation over a period of ten days. Agar plate-based assays were employed to assess the antimicrobial activity of these surfaces against Staphylococcus epidermidis. It was shown that vertically aligned MWCNTs were more stable against attrition on rough surfaces than on polished TiAl6V4 surfaces. Discs with coated surfaces caused a significant inhibition of biofilm formation for up to five days. Therefore, MWCNT-modified surfaces may be effective against pathogenic biofilm formation on endoprostheses.
AB - Bacterial biofilms cause a considerable amount of prosthetic joint infections every year, resulting in morbidity and expensive revision surgery. To address this problem, surface modifications of implant materials such as carbon nanotube (CNT) coatings have been investigated in the past years. CNTs are biologically compatible and can be utilized as drug delivery systems. In this study, multi-walled carbon nanotube (MWCNT) coated TiAl6V4 titanium alloy discs were fabricated and impregnated with Rifampicin, and tested for their ability to prevent biofilm formation over a period of ten days. Agar plate-based assays were employed to assess the antimicrobial activity of these surfaces against Staphylococcus epidermidis. It was shown that vertically aligned MWCNTs were more stable against attrition on rough surfaces than on polished TiAl6V4 surfaces. Discs with coated surfaces caused a significant inhibition of biofilm formation for up to five days. Therefore, MWCNT-modified surfaces may be effective against pathogenic biofilm formation on endoprostheses.
KW - Multi-walled carbon nanotubes
KW - Drug delivery system
KW - Biofilm
KW - S. epidermidis
KW - Antibiotics
KW - Prosthetic joint infection
U2 - 10.1016/j.nano.2017.01.002
DO - 10.1016/j.nano.2017.01.002
M3 - Article
SN - 1549-9634
VL - 13
SP - 1587
EP - 1593
JO - Nanomedicine: Nanotechnology, Biology and Medicine
JF - Nanomedicine: Nanotechnology, Biology and Medicine
IS - 4
ER -