TY - JOUR
T1 - Long-term population-based risks of second malignant neoplasms after childhood cancer in Britain
AU - Jenkinson, Helen
AU - Hawkins, Michael
AU - Stiller, CA
AU - Winter, David
AU - Marsden, HB
AU - Stevens, MCG
PY - 2004/12/31
Y1 - 2004/12/31
N2 - In a population-based, retrospective cohort study of 16 541 3-year survivors of childhood cancer treated in Britain up to the end of 1987, 278 second malignant neoplasms (SMNs) were identified against 39.4 expected giving a standardised incidence ratio (SIR) of 6.2. The overall cumulative risk of an SMN by 25 years from 3-year survival from childhood cancer was 4.2%. Analysis of the cohort of nonretinoblastoma childhood cancers combined revealed a significant decline in SIR of SMN with increasing duration of follow-up. There was a greater risk of developing a SMN, particularly secondary acute myeloid leukaemia, in those diagnosed with childhood cancer from 1980 onwards. However, on multivariate modeling, this was not an independent risk factor. There was significant heterogeneity (P
AB - In a population-based, retrospective cohort study of 16 541 3-year survivors of childhood cancer treated in Britain up to the end of 1987, 278 second malignant neoplasms (SMNs) were identified against 39.4 expected giving a standardised incidence ratio (SIR) of 6.2. The overall cumulative risk of an SMN by 25 years from 3-year survival from childhood cancer was 4.2%. Analysis of the cohort of nonretinoblastoma childhood cancers combined revealed a significant decline in SIR of SMN with increasing duration of follow-up. There was a greater risk of developing a SMN, particularly secondary acute myeloid leukaemia, in those diagnosed with childhood cancer from 1980 onwards. However, on multivariate modeling, this was not an independent risk factor. There was significant heterogeneity (P
KW - second malignant neoplasm
KW - childhood cancer
UR - http://www.scopus.com/inward/record.url?scp=11244252915&partnerID=8YFLogxK
U2 - 10.1038/sj.bjc.6602226
DO - 10.1038/sj.bjc.6602226
M3 - Article
C2 - 15534607
VL - 91
SP - 1905
EP - 1910
JO - British Journal of Cancer
JF - British Journal of Cancer
ER -
