Long-term impact of early treatment on radiographic progression in rheumatoid arthritis: A meta-analysis

A Finckh, MH Liang, CM van Herckenrode, Paola De Pablo

Research output: Contribution to journalArticle

331 Citations (Scopus)

Abstract

OBJECTIVE: Although early initiation of disease-modifying antirheumatic drugs (DMARDs) is effective in controlling short-term joint damage in individuals with rheumatoid arthritis (RA), the long-term benefit in disease progression is still controversial. We examined the long-term benefit of early DMARD initiation on radiographic progression in early RA. METHODS: We identified published and unpublished clinical trials and observational studies from 1966 to September 2004 examining the association between delay to treatment initiation and progressive radiographic joint damage. We included studies of persons with RA disease duration
Original languageEnglish
Pages (from-to)864-72
Number of pages9
JournalArthritis & Rheumatism
Volume55
Issue number6
DOIs
Publication statusPublished - 15 Dec 2006

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