Long-term effects of cardiac resynchronization therapy in octogenarians: a comparative study with a younger population.

Paul Foley, S Chalil, Kayvan Khadjooi, Russell Smith, Michael Frenneaux, F Leyva

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

AIMS: Heart failure is a disease of octogenarians. The evidence base for cardiac resynchronization therapy (CRT) has emerged from trials of patients in their 60s. We compared the effectiveness of CRT in octogenerians with younger patients. METHODS AND RESULTS: Patients aged >or=80 years [n = 53, age 83.7 +/- 2.6 years (mean +/- SD)] and or= 120 ms) underwent CRT. A clinical assessment, including a 6-min walk test, and a quality of life assessment (Minnesota Living with Heart Failure questionnaire) were undertaken at baseline and after CRT. In octogenarians, CRT was associated with similar changes in NYHA class [-1.28 vs. -1.22, P <0.0001 (P-values refer to changes from baseline)], 6-min walking distance (77.2 vs. 78.6 m, P <0.0001), and quality of life scores (-20.4 vs. -31.4, P = 0.0084) to or=1 NYHA classes or >or=25% 6-min walking distance) was observed in 80% of or=1 NYHA classes or >or=25% 6-min walking distance), a response was observed in 201 out of 277 (73%) patients
Original languageEnglish
Pages (from-to)1302-7
Number of pages6
JournalEuropace
Volume10
Issue number11
DOIs
Publication statusPublished - 1 Nov 2008

Keywords

  • Octogenarian
  • Mortality
  • Cardiac resynchronization therapy
  • Age
  • Heart failure

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