Local and systemic antioxidant capacity in periodontitis and health

Gareth Brock, C Butterworth, John Matthews, Iain Chapple

Research output: Contribution to journalArticle

206 Citations (Scopus)


BACKGROUND: The involvement of reactive oxygen species (ROS) in periodontal pathology is unclear but will be modulated by in vivo antioxidant defence systems. The aim of this cross-sectional study was to determine both local (saliva and gingival crevicular fluid (GCF) and peripheral (plasma and serum) antioxidant capacity in periodontal health and disease. MATERIALS AND METHODS: Twenty non-smoking volunteers with chronic periodontitis were sampled together with twenty age- and sex-matched, non-smoking controls. After overnight fasting, saliva (whole unstimulated and stimulated) and blood were collected. Total antioxidant capacity (TAOC) was determined using a previously reported enhanced chemiluminescence method. RESULTS: GCF antioxidant concentration was significantly lower (p
Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalJournal of Clinical Periodontology
Publication statusPublished - 1 Jan 2004


  • gingival crevicular fluid
  • plasma
  • periodontitis
  • gender
  • antioxidant


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