LMP1 structure and signal transduction

Aristides Eliopoulos, Lawrence Young

Research output: Contribution to journalArticle

175 Citations (Scopus)


The oncogenic Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has structural features and functions reminiscent of a constitutively active TNF family receptor. LMP1 aggregates at the plasma membrane and initiates the activation of signalling pathways, such as NF- kappa B, the mitogen-activated protein kinases JNK and p38, the small GTPase Cdc42 and the JAK/STAT cascade. The constitutive engagement of these signals and the characteristic molecular interactions that regulate them provide the basis for the molecular explanation of the transforming properties of this key EBV protein.
Original languageEnglish
Pages (from-to)435-444
Number of pages10
JournalSeminars in Cancer Biology
Issue number6
Publication statusPublished - 1 Dec 2001


  • LMP1
  • EBV
  • CD40
  • signalling


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