Liver retransplantation in adults: a single-centre, 25-year experience.

R Marudanayagam, V Shanmugam, B Sandhu, Bridget Gunson, DF Mirza, D Mayer, John Buckels, Simon Bramhall

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61 Citations (Scopus)


BACKGROUND Retransplantation is the only form of treatment for patients with irreversible graft failure. The aim of this study was to analyse a single centre's experience of the indications for and outcomes of retransplantation. METHODS A total of 196 patients who underwent liver retransplantation using 225 grafts, between January 1982 and July 2007, were included in the study. The following parameters were analysed: patient demographics; primary diagnosis; distribution of retransplantation over different time periods; indications for retransplantation; time interval to retransplantation, and overall patient and graft survival. RESULTS Of the 2437 primary orthotopic liver transplantations, 196 patients (8%) required a first regraft, 23 patients (1%) a second regraft and six patients (0.25%) a third regraft. Autoimmune hepatitis was the most common primary diagnosis for which retransplantation was required (12.7% of primary transplantations). The retransplantation rate declined from 12% at the beginning of our programme to 7.6% at the end of the study period. The most common indication for retransplantation was hepatic artery thrombosis (31.6%). Nearly two-thirds of the retransplantations were performed within 6 months of the primary transplantation. The 1-, 3-, 5- and 10-year patient survival rates following first retransplantation were 66%, 61%, 57% and 47%, respectively. Five-year survival after second retransplantation was 40%. None of the patients have yet survived 3 years after a third regraft. Donor age of <or =55 years and a MELD (Model for End-stage Liver Disease) score of <or =23 were associated with better outcome following retransplantation. CONCLUSIONS First retransplantation was associated with good longterm survival. There was no survival benefit following second and third retransplantations. A MELD score of <or =23 and donor age of <or =55 years correlated with better outcome following retransplantation.
Original languageEnglish
Pages (from-to)217-24
Number of pages8
JournalHPB : the official journal of the International Hepato Pancreato Biliary Association
Issue number3
Publication statusPublished - 1 Apr 2010


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