Lipid Profile, Plasma Apolipoproteins, and Risk of a First Myocardial Infarction Among Asians An Analysis From the INTERHEART Study

G Karthikeyan, KK Teo, S Islam, MJ McQueen, P Pais, X Wang, H Sato, CC Lang, C Sitthi-Amorn, MR Pandey, K Kazmi, John Sanderson, S Yusuf

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133 Citations (Scopus)

Abstract

Objectives This study sought to determine the prevalence of lipid and lipoprotein abnormalities and their association with the risk of a first acute myocardial infarction (AMI) among Asians. Background Patterns of lipid abnormalities among Asians and their relative impact on cardiovascular risk have not been well characterized. Methods In a case-control study, 65 centers in Asia recruited 5,731 cases of a first AMI and 6,459 control subjects. Plasma levels of lipids and apolipoproteins in the different Asian subgroups (South Asians, Chinese, Southeast Asians, and Japanese) were determined and correlated with the risk of AMI. Results Among both cases and controls, mean low-density lipoprotein cholesterol (LDL-C) levels were about 10 mg/dl lower in Asians compared with non-Asians. A greater proportion of Asian cases and controls had LDL-C
Original languageEnglish
Pages (from-to)244-253
Number of pages10
JournalJournal of the American College of Cardiology
Volume53
Issue number3
DOIs
Publication statusPublished - 1 Jan 2009

Keywords

  • lipoproteins
  • myocardial infarction
  • lipids

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