TY - JOUR
T1 - Lightweight sCMOS-based high-density diffuse optical tomography
AU - Bergonzi, Karla M
AU - Burns-Yocum, Tracy M
AU - Bumstead, Jonathan R
AU - Buckley, Elise M
AU - Mannion, Patrick C
AU - Tracy, Christopher H
AU - Mennerick, Eli
AU - Ferradal, Silvina L
AU - Dehghani, Hamid
AU - Eggebrecht, Adam T
AU - Culver, Joseph P
PY - 2018/7
Y1 - 2018/7
N2 - Though optical imaging of human brain function is gaining momentum, widespread adoption is restricted in part by a tradeoff among cap wearability, field of view, and resolution. To increase coverage while maintaining functional magnetic resonance imaging (fMRI)-comparable image quality, optical systems require more fibers. However, these modifications drastically reduce the wearability of the imaging cap. The primary obstacle to optimizing wearability is cap weight, which is largely determined by fiber diameter. Smaller fibers collect less light and lead to challenges in obtaining adequate signal-to-noise ratio. Here, we report on a design that leverages the exquisite sensitivity of scientific CMOS cameras to use fibers with
∼
30
×
smaller cross-sectional area than current high-density diffuse optical tomography (HD-DOT) systems. This superpixel sCMOS DOT (SP-DOT) system uses
200
-
μ
m
-diameter fibers that facilitate a lightweight, wearable cap. We developed a superpixel algorithm with pixel binning and electronic noise subtraction to provide high dynamic range (
>
10
5
), high frame rate (
>
6
Hz
), and a low effective detectivity threshold (
∼
200
fW
/
Hz
1
/
2
-
mm
2
), each comparable with previous HD-DOT systems. To assess system performance, we present retinotopic mapping of the visual cortex (
n
=
5
subjects). SP-DOT offers a practical solution to providing a wearable, large field-of-view, and high-resolution optical neuroimaging system.
AB - Though optical imaging of human brain function is gaining momentum, widespread adoption is restricted in part by a tradeoff among cap wearability, field of view, and resolution. To increase coverage while maintaining functional magnetic resonance imaging (fMRI)-comparable image quality, optical systems require more fibers. However, these modifications drastically reduce the wearability of the imaging cap. The primary obstacle to optimizing wearability is cap weight, which is largely determined by fiber diameter. Smaller fibers collect less light and lead to challenges in obtaining adequate signal-to-noise ratio. Here, we report on a design that leverages the exquisite sensitivity of scientific CMOS cameras to use fibers with
∼
30
×
smaller cross-sectional area than current high-density diffuse optical tomography (HD-DOT) systems. This superpixel sCMOS DOT (SP-DOT) system uses
200
-
μ
m
-diameter fibers that facilitate a lightweight, wearable cap. We developed a superpixel algorithm with pixel binning and electronic noise subtraction to provide high dynamic range (
>
10
5
), high frame rate (
>
6
Hz
), and a low effective detectivity threshold (
∼
200
fW
/
Hz
1
/
2
-
mm
2
), each comparable with previous HD-DOT systems. To assess system performance, we present retinotopic mapping of the visual cortex (
n
=
5
subjects). SP-DOT offers a practical solution to providing a wearable, large field-of-view, and high-resolution optical neuroimaging system.
U2 - 10.1117/1.NPh.5.3.035006
DO - 10.1117/1.NPh.5.3.035006
M3 - Article
C2 - 30137925
SN - 2329-423X
VL - 5
SP - 035006
JO - Neurophotonics
JF - Neurophotonics
IS - 3
ER -