Abstract
OBJECTIVES: Chronic stress has been associated with impaired response to influenza vaccination in the elderly. This study investigated whether mild, intermittent stress experienced by young, healthy adults has a similar effect. METHODS: Antibody and psychological status were determined prevaccination and 5 weeks and 5 months later; a fourfold increase in antibody to at least one viral strain was considered protective. RESULTS: At 5 months, unprotected participants reported significantly more life events and tended to report more perceived stress than those who were protected. CONCLUSIONS: Psychological stress is detrimental to long-term maintenance of antibody levels following vaccination in young, healthy adults.
| Original language | English |
|---|---|
| Pages (from-to) | 569-572 |
| Number of pages | 4 |
| Journal | Journal of Psychosomatic Research |
| Volume | 55 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Dec 2003 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- psychosocial stress
- psychoneuroimmunology
- vaccination
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