TY - JOUR
T1 - Levetiracetam treatment of idiopathic generalised epilepsy
AU - Krauss, GL
AU - Betts, Timothy
AU - Abou-Khalil, B
AU - Bergey, G
AU - Yarrow, Helen
AU - Miller, A
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Levetiracetam (LEV) is effective for treating localisation-related epilepsy, but it is uncertain whether it is effective for treating idiopathic generalised epilepsy. We compared 12-week baseline and LEV treatment periods for patients with generalised seizure types-myoclonic, tonic-clonic and absence seizures--who had failed other anticonvulsants. The majority of 55 patients (76%) had >50% seizure reduction with LEV therapy, 40% became seizure-free; 15% discontinued LEV due to adverse events, mostly sedation. This is preliminary evidence that LEV is effective for treating idiopathic generalised epilepsy.
AB - Levetiracetam (LEV) is effective for treating localisation-related epilepsy, but it is uncertain whether it is effective for treating idiopathic generalised epilepsy. We compared 12-week baseline and LEV treatment periods for patients with generalised seizure types-myoclonic, tonic-clonic and absence seizures--who had failed other anticonvulsants. The majority of 55 patients (76%) had >50% seizure reduction with LEV therapy, 40% became seizure-free; 15% discontinued LEV due to adverse events, mostly sedation. This is preliminary evidence that LEV is effective for treating idiopathic generalised epilepsy.
KW - levetiracetam
KW - seizures
KW - generalised epilepsy
UR - http://www.scopus.com/inward/record.url?scp=0344668608&partnerID=8YFLogxK
U2 - 10.1016/S1059-1311(03)00139-0
DO - 10.1016/S1059-1311(03)00139-0
M3 - Article
C2 - 14630506
VL - 12
SP - 617
EP - 620
JO - Seizure
JF - Seizure
IS - 8
ER -