Lessons from Toxoplasma: Host responses that mediate parasite control and the microbial effectors that subvert them

Eva-Maria Frickel, Christopher A Hunter

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Abstract

The intracellular parasite Toxoplasma gondii has long provided a tractable experimental system to investigate how the immune system deals with intracellular infections. This review highlights the advances in defining how this organism was first detected and the studies with T. gondii that contribute to our understanding of how the cytokine IFN-γ promotes control of vacuolar pathogens. In addition, the genetic tractability of this eukaryote organism has provided the foundation for studies into the diverse strategies that pathogens use to evade antimicrobial responses and now provides the opportunity to study the basis for latency. Thus, T. gondii remains a clinically relevant organism whose evolving interactions with the host immune system continue to teach lessons broadly relevant to host-pathogen interactions.

Original languageEnglish
Article numbere20201314
JournalThe Journal of Experimental Medicine
Volume218
Issue number11
Early online date20 Oct 2021
DOIs
Publication statusPublished - 1 Nov 2021

Bibliographical note

© 2021 Frickel and Hunter.

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