Left ventricular pacing minimizes diastolic ventricular interaction, allowing improved preload-dependent systolic performance

RA Bleasdale, MS Turner, CE Mumford, P Steendijk, V Paul, JV Tyberg, JA Morris-Thurgood, Michael Frenneaux

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

BACKGROUND: Left ventricular (LV) pacing improves hemodynamics in patients with heart failure. We hypothesized that at least part of this benefit occurs by minimization of external constraint to LV filling from ventricular interaction. METHODS AND RESULTS: We present median values (interquartile ranges) for 13 heart failure patients with LV pacing systems implanted for New York Heart Association class III/IV limitation. We used the conductance catheter method to measure LV pressure and volume simultaneously. External constraint was measured from the end-diastolic pressure-volume relation recorded during inferior vena caval occlusion, during LV pacing, and while pacing was suspended. External constraint to LV filling was reduced by 3.0 (4.6 to 0.6) mm Hg from 4.8 (0.6 to 7.5) mm Hg (P
Original languageEnglish
Pages (from-to)2395-2400
Number of pages6
JournalCirculation
Volume110
DOIs
Publication statusPublished - 1 Jan 2004

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